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个人简介
Wiebke’s research focus is the exploration of the role of steroid synthesis and metabolism in human health and disease. Her work has identified the key role of adrenal androgens in women, establishing DHEA replacement in women with adrenal insufficiency (N Engl J Med 1999). She has discovered the molecular basis of novel androgen excess disorders (POR deficiency, Lancet 2004; PAPSS2 deficiency, N Engl J Med 2009), leading to new insights into pathways of human androgen synthesis and metabolism.
As a Wellcome Trust Investigator, she applies an integrated systems medicine approach to the dissection of androgen excess and metabolic dysfunction in the context of polycystic ovary syndrome (PCOS). To this end, she combines state-of-the-art human in vivo physiology, innovative ex vivo and in vitro approaches and the exploration of the steroid and global metabolome by machine learning-based computational tools. Her group also applies this steroid metabolomics approach, the combination of mass spectrometry-based steroid profiling with machine learning-based data analysis, to the delineation of steroid excess and metabolic impact in the context of endocrine hypertension and adrenal tumours.
Wiebke leads the Dissecting Androgen excess and metabolic dysfunction – an Integrated Systems approach to PolyCystic Ovary Syndrome (Daisy PCOS) Research Project. It's a new research study which examines the metabolic nature of PCOS and its links to other health conditions. Please see the new website for more information and about the public engagement programme.
研究兴趣
论文共 737 篇作者统计合作学者相似作者
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Hamish Miller,David Harman,Guruprasad Padur Aithal,Pinelopi Manousou,Jeremy F Cobbold,Richard Parker,David Sheridan,Philip N Newsome,Fredrik Karpe, Matthew Neville,Wiebke Arlt,Alice J Sitch,
BMJ Openno. 1 (2024): e074918-e074918
Laura C. Sommerfeld,Andrew P. Holmes,Ting Y. Yu, Christopher O'Shea,Deirdre M. Kavanagh,Jeremy M. Pike,Thomas Wright,Fahima Syeda, Areej Aljehani, Tania Kew, Victor R. Cardoso,S. Nashitha Kabir,
JOURNAL OF PHYSIOLOGY-LONDON (2024)
The Journal of Steroid Biochemistry and Molecular Biology (2024): 106436-106436
Juliet Richards, Ai Chiin Lim,Colin W. Hay,Angela E. Taylor,Anna Wingate,Karolina Nowakowska,Carmel Pezaro,Suzanne Carreira,Jane Goodall,Wiebke Arlt,Iain J. McEwan, Johann S. de Bono,
crossref(2023)
R. J. M. Ross,Aled Rees, Merke Deborah P.,Wiebke Arlt, De La Perriere Aude Brac, Hirschberg Angelica Linden,Anders Juul, C. Newell-Price John D.,Colin Perry,Alessandro Prete,Nicole Reisch, Monica Stikkelbroeck,
Endocrine Abstracts (2023)
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Juliet Richards, Ai Chiin Lim,Colin W. Hay,Angela E. Taylor,Anna Wingate,Karolina Nowakowska,Carmel Pezaro,Suzanne Carreira,Jane Goodall,Wiebke Arlt,Iain J. McEwan, Johann S. de Bono,
crossref(2023)
Sumedha Mandal, Pratyusha Saha, Onnicha Suntornlohanakul, Shadman Ahmed, Jessica Parkin-Crawshaw,Miriam Asia,Wiebke Arlt,Yasir Elhassan,Alessandro Prete, Cristina Rabascio
Endocrine Abstracts (2023)
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Mirna Elghobashy, Gar Mun Lau,Meri Davitadze, Caroline D. T. Gillett,Michael W. O'Reilly,Wiebke Arlt, Antje PCOS SEva Working Grp,Antje Lindenmeyer,Punith Kempegowda
FRONTIERS IN ENDOCRINOLOGY (2023): 1175548-1175548
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