Wenwei Lin - St. Jude Children's Research Hospital

基本信息

Career Trajectory

Bio

Wenwei Lin currently works at the Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital with a typical chemistry approach to address biology questions. Wenwei extensively explores biological assays and related high Throughput Screening in the fields of Cancer Research, Cell Biology and Molecular Biology with an emphasis in the areas of nuclear receptors, epigenetics, kinases, transporters and enzymes.

Research Interests

Papers共 90 篇Author StatisticsCo-AuthorSimilar Experts

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Development of a Tumor-Region-selective Activation Monoclonal Antibody Targeting the 4-1BB Receptor for Enhanced Therapeutic Efficacy and Safety

Tzu-Yi Liao,Yen-Ling Liu, Chiao-Yun Chen, Bing-Tsung Wu,En-Shuo Liu,Shih-Ting Hong,Bo-Cheng Huang,Yi-An Cheng,Michael Chen,Kuo-Hsiang Chuang,Wen-Wei Lin,Chih-Hung Chuang,Fang-Ming Chen,Kai-Wen Ho,Tian-Lu Cheng

International journal of biological macromoleculesno. Pt 2 (2025): 141003-141003

Cited0Views0WOSBibtex

459 Development of Small Molecules Targeting an Epigenetic Modulator for Pediatric Neuroblastoma

Joseph McPherson, William Pomerantz, Molly Sneddon,Anang Shelat,Wenwei Lin,Taosheng Chen,Marcus Fischer,Natalia Tretyakova

Journal of Clinical and Translational Science (2025): 135-135

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First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy

Andrew D. Huber, Young-Hwan Jung,Yongtao Li,Wenwei Lin,Jing Wu,Shyaron Poudel, Annalise G. Carrigan,Ashutosh Mishra,Anthony A. High,Taosheng Chen

JOURNAL OF MEDICINAL CHEMISTRYno. 20 (2024): 18549-18575

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Development of BODIPY FL SNS 032 As a Versatile Probe for Constitutive Androstane Receptor and Multiple Kinases

Wenwei Lin,Taosheng Chen

ACS medicinal chemistry lettersno. 11 (2024): 1987-1996

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PROTAC-mediated Activation, Rather Than Degradation, of a Nuclear Receptor Reveals Complex Ligand-Receptor Interaction Network

Andrew D. Huber,Wenwei Lin,Shyaron Poudel,Darcie J. Miller,Taosheng Chen

STRUCTUREno. 12 (2024)

Cited2Views0WOSBibtex

Ligand Flexibility and Binding Pocket Malleability Cooperate to Allow Selective PXR Activation by Analogs of a Promiscuous Nuclear Receptor Ligand

Andrew D. Huber,Shyaron Poudel,Yongtao Li,Wenwei Lin,Jing Wu,Darcie J. Miller,Taosheng Chen

STRUCTUREno. 12 (2023)

Cited6Views0WOSBibtex

Structure-guided Approach to Modulate Small Molecule Binding to a Promiscuous Ligand-Activated Protein

Wenwei Lin,Andrew D. Huber,Shyaron Poudel,Yongtao Li,Jayaraman Seetharaman,Darcie J. Miller,Taosheng Chen

Proceedings of the National Academy of Sciences（2023）

Cited10Views0WOSBibtex

Structure-guided Approach to Modulate Small Molecule Binding to the Promiscuous Pregnane X Receptor

Andrew D. Huber,Wenwei Lin,Shyaron Poudel,Yongtao Li,Jayaraman Seetharaman,Darcie J. Miller,Taosheng Chen

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)

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A Bromodomain-Independent Mechanism of Gene Regulation by the BET Inhibitor JQ1: Direct Activation of Nuclear Receptor PXR

Andrew D. Huber,Shyaron Poudel,Jing Wu,Darcie J. Miller,Wenwei Lin,Lei Yang,Monicah N. Bwayi,Mary Ashley Rimmer,Rebecca R. Florke Gee,Jayaraman Seetharaman,Sergio C. Chai,Taosheng Chen

Nucleic Acids Researchno. 4 (2023): 1661-1676

Cited2Views0WOSBibtex

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