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My laboratory is focused on studying the regulation of Na+ and K+ transport in aldosterone-sensitive distal tubules of the kidney. Na+ is a major extracellular ion and plays a key role in maintaining extracellular volume, and decreasing extracellular Na+ content can result in hypotension whereas increasing Na+ content causes hypertension. Conversely, K+ is mainly located in the intracellular fluid and extracellular K+ must be maintained in a narrow range: either high plasma K+ (hyperkalemia) or low plasma K+ (hypokalemia) can cause life-threatening cardiac arrhythmias. The kidney plays a key role in secreting K+ to match the dietary K+ intake, and disorders of K+ balance are common in patients with kidney failure.
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Xin-Peng Duan,Jun-Ya Zheng, Shao-Peng Jiang,Ming-Xiao Wang,Chengbiao Zhang, Tanzina Chowdhury,Wen-Hui Wang,Dao-Hong Lin
Journal of the American Society of Nephrology : JASN (2024)
Rolando Carrisoza-Gaytan,Stephanie M. Mutchler, Francisco Carattino, Joanne Soong,Marianela G. Dalghi,Peng Wu,WenHui Wang,Gerard Apodaca,Lisa M. Satlin,Thomas R. Kleyman
Journal of the American Society of Nephrology : JASN (2024)
Hypertension (Dallas, Tex. : 1979)no. 1 (2024): 126-137
Yujiro Maeoka,Xin-Peng Duan,Luan Nguyen,Avika Sharma, Marissa Gutierrez,Wen-Hui Wang,James McCormick
Physiologyno. S1 (2024)
Bidisha Saha,Waheed Shabbir,Enzo Takagi,Xin-Peng Duan, Deise Carla Almeida Leite Dellova,John Demko,Anna Manis,Dominique Loffing-Cueni,Johannes Loffing,Mads Vaarby Sørensen,Wen-Hui Wang,David Pearce
Journal of the American Society of Nephrology : JASNno. 6 (2023): 1019-1038
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