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Bio
Dr. Ho and the department of pathology study factors that impact the interplays between the host cell innate immunity and viral infections, particularly HIV. The Lab uses in vitro, ex vivo models and clinical specimens to address three key questions: A. How does HIV infect and stay in the macrophages that possess multiple viral recognition and control mechanisms? B. Are non-immune cells at the primary HIV infection sites involved in the host innate immunity against HIV? C. Are drugs of abuse a negative factor that suppresses the host cell innate immunity against HIV infection? The current research in the Ho Lab focuses on the following areas:
1. To examine the immune and non-immune cells-mediated innate immunity (TLRs, RIG-I, and DNA sensors) that recognize and control HIV infection/replication. The cells under examination include the immune cells (T cells, monocytes/macrophages, and microglia) and non-immune cells in the CNS (neurons and astrocytes), gastrointestinal and female reproductive tracks (endothelial cells and epithelial cells).
2. To study whether drugs (opioids and methamphetamine) of abuse impair the host cell innate immunity and facilitate HIV infection.
3. To use newly developed iPSC-derived CNS cells and brain organoid to determine the role of abused drugs in HIV infection of primary target/reservoir cells in the CNS.
1. To examine the immune and non-immune cells-mediated innate immunity (TLRs, RIG-I, and DNA sensors) that recognize and control HIV infection/replication. The cells under examination include the immune cells (T cells, monocytes/macrophages, and microglia) and non-immune cells in the CNS (neurons and astrocytes), gastrointestinal and female reproductive tracks (endothelial cells and epithelial cells).
2. To study whether drugs (opioids and methamphetamine) of abuse impair the host cell innate immunity and facilitate HIV infection.
3. To use newly developed iPSC-derived CNS cells and brain organoid to determine the role of abused drugs in HIV infection of primary target/reservoir cells in the CNS.
Research Interests
Papers共 268 篇Author StatisticsCo-AuthorSimilar Experts
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Tai-Wei Li, Youngmin Park, Emily G. Watters,Xu Wang,Dawei Zhou,Guillaume N. Fiches,Zhenyu Wu,Andrew D. Badley, Jonah B. Sacha,Wen-Zhe Ho, Netty G. Santoso,Jun Qi,
Antiviral research (2024): 105947-105947
Yu Liu,Xi-Qiu Xu, Wei-Jing Li,Biao Zhang,Feng-Zhen Meng,Xu Wang, Safah M Majid, Zihan Guo,Wen-Zhe Ho
Frontiers in cellular and infection microbiology (2024): 1383811-1383811
crossref(2024)
Virusesno. 7 (2024)
Experimental neurology (2023): 114386-114386
Molecular therapy : the journal of the American Society of Gene Therapyno. 4 (2023): 1136-1158
biorxiv(2022)
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