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During Wei’s postdoctoral training with Dr. David Sherwood at Duke University and Dr. Kang Shen at Stanford University, he has identified several novel dendritic guidance molecules. Among these, LECT-2, the homologue of human LECT2, acts as a co-ligand with two cell adhesion molecules SAX-7/L1CAM and MNR-1/Menorin. These three molecules form a co-ligand complex, which is recognized by the dendritic receptor DMA-1. Activation of DMA-1 requires the presence of each molecule, suggestive of a co-incidence detection mode of recognition to specify the precise location of dendritic arbors.
He also found that HPO-30, a claudin-like protein, functions as a co-receptor of DMA-1. HPO-30 and DMA-1 recruit WAVE regulatory complex and TIAM-1/RacGEF, respectively, to promote actin assembly and dendrite formation. To the best of our knowledge, this is the first case to show that a claudin acts as a signaling molecule rather than as a component of tight junctions during neural development.
He also found that HPO-30, a claudin-like protein, functions as a co-receptor of DMA-1. HPO-30 and DMA-1 recruit WAVE regulatory complex and TIAM-1/RacGEF, respectively, to promote actin assembly and dendrite formation. To the best of our knowledge, this is the first case to show that a claudin acts as a signaling molecule rather than as a component of tight junctions during neural development.
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JOURNAL OF AFFECTIVE DISORDERS (2024): 600-611
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2024): 173677-173677
Duo Zhang,Abigail H. Cleveland, Elisavet Krimitza, Katherine Han, Chenlong Yi,Andrea L. Stout,Wei Zou,Jay F. Dorsey,Yanqing Gong,Yi Fan
Nature Protocolsno. 4 (2024): 1-30
Journal of Physiology and Biochemistryno. 2 (2024): 1-13
Rebecca Shi, Xue Yan Ho,Li Tao,Caitlin A Taylor,Ting Zhao,Wei Zou, Malcolm Lizzappi,Kelsie Eichel,Kang Shen
bioRxiv : the preprint server for biology (2024)
Neuroscience Research (2024)
CLINICAL CANCER RESEARCHno. 22 (2023): 4596-4605
Metabolic brain diseaseno. 8 (2023): 2505-2520
Communications Biologyno. 1 (2023): 1-13
Yujuan Fu,Yaxin Liu,Tanye Wen,Jie Fang, Yalong Chen, Ziying Zhou, Xinyi Gu,Hao Wu,Jinghao Sheng,Zhengping Xu,Wei Zou,Baohui Chen
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