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个人简介
Dr. Zhang is a leader of precision oncology, using NFCR support since 2006 to characterize underlying genetic mechanisms responsible for cancer growth and progression. His research addresses the variability in cellular properties, within and across cancer types, which often leads to treatment resistance and poor survival in patients. For example, African-Americans diagnosed with lung cancer have higher incidences and lower survival rates than Caucasian Americans. Utilizing leading-edge genomic techniques, Dr. Zhang discovered that lung cancer in African-Americans expressed higher immunosuppressive components, permitting the lung cancer to escape attack by their immune system.
Dr. Zhang’s research has advanced our understanding of the role of genetic mutations in cancer progression and treatment: 1) lung cancer in African-Americans expresses a mutation in the TP53 tumor suppressor gene, leading to shorter survival times; 2) daily alcohol consumption causes DNA damage and changes in over 600 genes shown to be involved in cancer development; and 3) development of new computational methods utilizing artificial intelligence can predict the origin of cancers that have metastasized to the brain. Dr. Zhang’s precision oncology approach has the potential to improve outcomes for patients with non-Hodgkin’s lymphoma and leukemia, melanoma, and cancers of the lung, gastrointestinal tract, pancreas, ovary, uterus, brain and liver.
Dr. Zhang’s research has advanced our understanding of the role of genetic mutations in cancer progression and treatment: 1) lung cancer in African-Americans expresses a mutation in the TP53 tumor suppressor gene, leading to shorter survival times; 2) daily alcohol consumption causes DNA damage and changes in over 600 genes shown to be involved in cancer development; and 3) development of new computational methods utilizing artificial intelligence can predict the origin of cancers that have metastasized to the brain. Dr. Zhang’s precision oncology approach has the potential to improve outcomes for patients with non-Hodgkin’s lymphoma and leukemia, melanoma, and cancers of the lung, gastrointestinal tract, pancreas, ovary, uterus, brain and liver.
研究兴趣
论文共 370 篇作者统计合作学者相似作者
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Lauren Schmalz, Cetin Urtis, Liang Liu,Elizabeth Forbes, Fang-Chi Hsu, Nury Steuerwald, Alberto de Hoyos,Thomas Lycan,Jimmy Ruiz,William Petty,Wei Zhang
Cancer Researchno. 6_Supplement (2024): 5065-5065
Journal of Healthcare Informatics Researchpp.1-19, (2024)
Meeri Pekkarinen,Kristiina Nordfors,Joonas Uusi-Mäkelä,Ville Kytölä, Anja Hartewig, Laura Huhtala, Minna Rauhala, Henna Urhonen, Sergei Häyrynen,Ebrahim Afyounian,Olli Yli-Harja,Wei Zhang,
bioRxiv (Cold Spring Harbor Laboratory)no. 6 (2024)
Cancer Researchno. 6_Supplement (2024): 6126-6126
Cancer Researchno. 6_Supplement (2024): 2650-2650
Kimberly M. Burcher,Chance H. Bloomer,Elena Gavrila, John M. Kalada,Mark J. Chang, Rediet R. Gebeyehu,Alexander H. Song, Lara M. Khoury,Thomas W. Lycan, Rebecca Kinney, Ralph D'Agostino Jr,Paul M. Bunch,
Therapeutic Advances in Medical Oncology (2024): 17588359231217959-17588359231217959
crossref(2023)
Kirsi Rautajoki,Serafiina Jaatinen, Anja Hartewig,Aliisa M Tiihonen,Matti Annala, Iiris Salonen,Mari Valkonen, Vili Simola,Elisa M. Vuorinen, A. Kivinen, Minna Rauhala, Riikka Nurminen,
Neuro-Oncologyno. Supplement_2 (2023): ii65-ii65
Ryan T Hughes,Rediet R Gebeyehu, John Mason Kalada,Thomas W Lycan,Bart A Frizzell, Rebecca D Kinney,Ralph B D'Agostino,Paul M Bunch,Pierre Triozzi,Wei Zhang,Cristina M Furdui,Mercedes Porosnicu
crossref(2023)
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