Wei Lemaire

Department of Depression and Circadian Disorders Merck Research Laboratories

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论文共 54 篇作者统计合作学者相似作者

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Virtual Screening for Early Identification of Potent and Selective Histone Deacetylase 6 Inhibitor Series

Shawn J. Stachel,Deping Wang,Anthony T. Ginnetti, Shahriar Niroomand,Lei Ma, Yinghui Hu,John F. Fay,Wei Lemaire,Daniel J. Krosky,Andres D. Ramirez, Hatim A. Zariwala,Paul J. Coleman

Bioorganic & Medicinal Chemistry Letters (2023): 129537-129537

引用0浏览0WOS引用

Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections

H. Marie Loughran,Kathy M. Schirripa,Anthony J. Roecker,Michael J. Breslin,Ling Tong,Kerry L. Fillgrove,Yuhsin Kuo,Kelly Bleasby,Hannah Collier,Michael D. Altman,Melissa C. Ford,Justin A. Newman,Robert E. Drolet,Mali Cosden,Sarah Jinn,Rosemarie B. Flick, Xiaomei Liu,Christina Minnick,Marla L. Watt,Wei Lemaire,Christine Burlein,Gregory C. Adam,Lauren A. Austin,Jacob N. Marcus,Sean M. Smith,Mark E. Fraley

ACS MEDICINAL CHEMISTRY LETTERSno. 1 (2023): 123-131

引用0浏览0WOS引用

Pyrazole Ureas As Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease

Anthony J. Roecker,Kathy M. Schirripa,H. Marie Loughran,Ling Tong, Tao Liang,Kerry L. Fillgrove,Yuhsin Kuo,Kelly Bleasby,Hannah Collier,Michael D. Altman,Melissa C. Ford,Robert E. Drolet,Mali Cosden,Sarah Jinn,Nathan G. Hatcher,Lihang Yao,Monika Kandebo,Joshua D. Vardigan,Rosemarie B. Flick, Xiaomei Liu,Christina Minnick, Laura A. Price,Marla L. Watt,Wei Lemaire,Christine Burlein,Gregory C. Adam,Lauren A. Austin,Jacob N. Marcus,Sean M. Smith,Mark E. Fraley

ACS Medicinal Chemistry Letters（2023）

引用3浏览0WOS引用

Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction

Douglas C. Beshore,Gregory C. Adam,Richard J. O. Barnard,Christine Burlein,Steven N. Gallicchio,M. Katharine Holloway,Daniel Krosky,Wei Lemaire,Robert W. Myers,Sangita Patel,Michael A. Plotkin,David A. Powell,Vanessa Rada,Christopher D. Cox,Paul J. Coleman,Daniel J. Klein,Scott E. Wolkenberg

ACS medicinal chemistry letters（2021）

引用14浏览0WOS引用

A Novel Glucosylceramide Synthase Inhibitor Attenuates Alpha Synuclein Pathology and Lysosomal Dysfunction in Preclinical Models of Synucleinopathy

Mali Cosden,Sarah Jinn,Lihang Yao,Cheryl A. Gretzula,Monika Kandebo,Dawn Toolan,Nathan G. Hatcher,Lei Ma,Wei Lemaire,Gregory C. Adam,Christine Burlein,Christina Minnick,Rose Flick,Marla L. Watt,James Mulhearn,Mark Fraley,Robert E. Drolet,Jacob N. Marcus,Sean M. Smith

NEUROBIOLOGY OF DISEASE（2021）

引用15浏览0WOS引用

Discovery of Diazepane Amide DORAs and 2-Soras Enabled by Exploration of Isosteric Quinazoline Replacements

Anthony J. Roecker,Swati P. Mercer,Jeffrey M. Bergman,Kevin F. Gilbert,Scott D. Kuduk,C. Meacham Harrell,Susan L. Garson,Steven V. Fox,Anthony L. Gotter,Pamela L. Tannenbaum,Thomayant Prueksaritanont,Tamara D. Cabalu,Donghui Cui,Wei Lemaire,Christopher J. Winrow,John J. Renger,Paul J. Coleman

Bioorganic & Medicinal Chemistry Letters（2015）

引用20浏览0WOS引用

Discovery And Characterization Of Ox2r/Ox1r And Ox2r Antagonists For The Treatment Of Sleep Disorders

Paul J. Coleman,Christopher D. Cox,Michael J. Breslin,John D. Schreier,Anthony J. Roecker,David B. Whitman,Swati P. Mercer,Pamela L. Tannenbaum,Anthony L. Gotter,Susan L. Garson,Steven V. Fox,C. Meacham Harrell,Joanne Stevens,Scott M. Doran,Duane R. Reiss,Wei Lemaire,Joseph J. Bruno,Tamara D. Cabalu,Donghui Cui,Thomayant Prueksaritanont,Steven D. Young,George D. Hartman,Christopher J. Winrow,John J. Renger

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY（2014）

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Discovery And Optimization Of A Series Of Pyrimidine Pde10 Inhibitors Through Fragment Screening, Structure-Based Design, And Parallel Synthesis

William D. Shipe,Pravien D. Abeywickrema,James C. Barrow, Rodney Bednar,Joseph Bruno,Victoria Cofre,Paul J. Coleman,Delphine Collin,Christopher D. Cox,Christine Fandozzi,Krista Getty,Sarah Huszar,Peter Hutson,Amanda Kemmerer,Raghu Krishnan,Wei Lemaire,Bennett Ma,Georgia Mcgaughey,Sanjeev Munshi, Shannon Nguyen, Mark B. Nolt,Sophie Parmentier-Batteur,Izzat T. Raheem,Steven S. Sharik,Sujata Sharma, Sean Smith, Cory Theberge,Jason Uslaner,Youwei Yan

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY（2014）

引用0浏览0引用

Discovery And Early Development Of Mk-1064: A Potent, Orally Bioavailable, Selective Orexin 2 Receptor Antagonist (2-Sora) For The Treatment Of Insomnia

Anthony J. Roecker,Swati P. Mercer,Christopher D. Cox,Mark E. Fraley,John D. Schreier,Justin T. Steen,Pamela L. Tannenbaum,Anthony L. Gotter,Susan L. Garson,Steven V. Fox,C. Meacham Harrell,Joanne Stevens,Wei Lemaire,Joseph G. Bruno,Joyce Stellabott,John D. Higgins,Tamara D. Cabalu,Dan Cui,Thomayant Prueksaritanont,George D. Hartman,Steven D. Young,Christopher J. Winrow,John J. Renger,Mark S. Forman,Paul J. Coleman

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY（2014）

引用0浏览0引用

Discovery of MK-3697: a Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia

Anthony J. Roecker,Thomas S. Reger,M. Christa Mattern,Swati P. Mercer,Jeffrey M. Bergman,John D. Schreier,Rowena V. Cube,Christopher D. Cox,Dansu Li,Wei Lemaire,Joseph G. Bruno,C. Meacham Harrell,Susan L. Garson,Anthony L. Gotter,Steven V. Fox,Joanne Stevens,Pamela L. Tannenbaum,Thomayant Prueksaritanont,Tamara D. Cabalu,Donghui Cui,Joyce Stellabott,George D. Hartman,Steven D. Young,Christopher J. Winrow,John J. Renger,Paul J. Coleman

Bioorganic & Medicinal Chemistry Letters（2014）

引用29浏览0WOS引用

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作者统计

#Papers: 54

#Citation: 2652

H-Index: 23

G-Index: 34

Sociability: 6

Diversity: 2

Activity: 3

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