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Research Abstract:
As components of the innate immune system, natural killer (NK) cells help defend the host from pathogens and cancer while the adaptive immune system is being mustered. We are particularly interested in NK cell responses with respect to the “missing-self” hypothesis that originally postulated that NK cells are prevented from killing by normal expression of ubiquitously expressed major histocompatibility complex class I (MHC-I) molecules on targets. When MHC-I is down-regulated (“missing”), then NK cells attack. Over the years, we have identified and characterized germline-encoded NK cell receptors that help explain missing-self, including inhibitory receptors for MHC-I that block the function of NK cell activation receptors that in turn recognize other target cell surface ligands, including virus-encoded ligands. Moreover, we showed that the inhibitory receptors ironically have a second function in licensing or educating individual NK cells by recognition of self-MHC-I in the host. Licensing allows the NK cell to be functionally competent to be triggered by their activation receptors. Our current work includes use of CRISPR-Cas9 to develop mice expressing only one receptor on all NK cells, allowing definitive analysis of how these receptors guide innate immune and NK cell functions in host responses to tumors and viruses.
Our lab also works on translational human immune studies, particularly in autoimmunity and HIV. We also study immune responses to viruses, including a mouse virus that induces autoimmunity.
Research Interests
Papers共 315 篇Author StatisticsCo-AuthorSimilar Experts
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Sytse J Piersma, Shasha Li, Pamela Wong, Michael D Bern,Jennifer Poursine-Laurent,Liping Yang,Diana L Beckman,Bijal A Parikh,Wayne M Yokoyama
bioRxiv : the preprint server for biology (2024)
Changxu Fan,Xiaoyun Xing, Samuel J H Murphy,Jennifer Poursine-Laurent,Heather Schmidt,Bijal A Parikh, Jeesang Yoon,Mayank N K Choudhary, Naresha Saligrama,Sytse J Piersma,Wayne M Yokoyama,Ting Wang
Nature communicationsno. 1 (2024): 4839-4839
IMMUNITYno. 2 (2023): 225-226
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Nature Communicationsno. 1 (2023): 1-17
Sytse J. Piersma,Sushant Bangru, Jeesang Yoon, Tom W. Liu,Liping Yang,Chyi-Song Hsieh,Beatrice Plougastel-Douglas,Auinash Kalsotra,Wayne M. Yokoyama
Michael A. Paley,Lynn Hassman,Xinbo Yang,Nicole Linskey,Ekaterina Esaulova,Grace L. Paley,Philip Ruzycki, Jennifer Laurent, Lacey Feigl-Lenzen,Max Artyomov,K. Chris Garcia,Wayne M. Yokoyama
Journal of Immunologyno. 1 (2023): 155.01-155.01
EUROPEAN JOURNAL OF IMMUNOLOGY (2023): 15-15
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ARTHRITIS & RHEUMATOLOGY (2023): 100-101
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Frontiers in Immunology (2023)
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