Yi-Ching Wang

Yi-Ching Wang investigates the etiological association of alterations in tumor suppressor genes and oncogenes with lung tumorigenesis. She has continued to do research on cancer genomics and epigenomics to identify new genes critical to lung tumorigenesis. More recently, her group focuses on the role of Rab37 small GTPase in regulation of exocytosis and malfunction of Rab37 in tumorigenesis and tumor microenvironment. In addition, her team establishes the first transcription network of Oct4 stemness factor in somatic lung cancer cells. Notably, her group identifies an oncogenic zinc finger transcription factor ZNF322A and investigates the underlying mechanisms of ZNF322A in cancer progression. Several potential anti-cancer drugs also are developing in her laboratory.