His research interest focuses on exploring chemical tools including chemical library synthesis and HTS, and functional chemical probes to modulate the cancer related biological targets and signaling pathways and optimize hit compounds to lead drug candidates for cancer clinical studies. The targets include kinases, and protein-protein and -DNA/RNA interactions and cancer immunotherapy. A particular strength of his research is the utilization of multidisciplinary approaches crossing chemical and biomedical fields to answer the specific biological questions through collaborative efforts.