基本信息
浏览量:52
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Research in our laboratory focuses on studying the human polyomaviruses, JCPyV and BKPyV. JCPyV and BKPyV both infect greater than 60% of the human population worldwide. The viruses establish life-long persistent infection in the kidney and are excreted in the urine. In immunosuppressed patients or in patients being treated with immunomodulatory drugs JCPyV spreads to the central nervous system (CNS) where it infects oligodendrocytes causing a fatal demyelinating disease known as progressive multifocal leukoencephalopathy (PML). Reactivation of BKPyV in kidney and bone marrow transplant recipients gives rise to polyomavirus nephropathy and hemorrhagic cystitis and has emerged as a major contributor to transplant failure. Our major goals are to understand mechanisms of persistence, reactivation, and virus tropism that leads to the development of polyomavirus induced disease. Our efforts are largely but not exclusively focused on identifying receptor dependent and receptor independent mechanisms of infection, identifying early biomarkers of disease, and developing strategies to prevent or treat PML.
研究兴趣
论文共 127 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Journal of virologyno. 4 (2024): e0028224-e0028224
JOURNAL OF VIROLOGY (2024)
International journal of molecular sciencesno. 10 (2023): 8580-8580
Jenna Morris-Love,Bethany A O'Hara,Gretchen V Gee,Aisling S Dugan, Ryan S O'Rourke, Brandon E Armstead,Benedetta Assetta,Sheila A Haley,Walter J Atwood
Journal of extracellular biologyno. 5 (2022)
Bethany A O'Hara,Gretchen V Gee,Sheila A Haley,Jenna Morris-Love, Charlotte Nyblade, Chris Nieves,Barbara A Hanson,Xin Dang,Timothy J Turner,Jeffrey M Chavin,Alex Lublin,Igor J Koralnik,
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn