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Research Summary
Sterile Inflammation: Inflammation occurs in response to tissue injury even in the absence of signals from pathogens. There are numerous examples of this, from soft tissue swelling after trauma to the inflammatory infiltrate after a myocardial infarction. In the liver a number of clinically important conditions have a significant sterile inflammatory component. These include drug induced liver injury, alcoholic, and non-alcoholic liver disease. We have recently identified a two signals pathway consisting of activation of TLR9 by DNA from apoptotic self cells, and also activation of the inflammasome pathway. In addition we have found that the cheap and safe anti-inflammatory drug aspirin can inhibit the TLR9 mediated pathway. We are expanding these findings to test their general applicability to a wide range of liver diseases and also to further identify the role of up-stream activating steps including nuclear DNA, and metabolites of the uric acid pathway.
Specialized Terms: Non-alcoholic hepatitis, Sterile inflammation; Liver fibrosis; Liver immunology
Sterile Inflammation: Inflammation occurs in response to tissue injury even in the absence of signals from pathogens. There are numerous examples of this, from soft tissue swelling after trauma to the inflammatory infiltrate after a myocardial infarction. In the liver a number of clinically important conditions have a significant sterile inflammatory component. These include drug induced liver injury, alcoholic, and non-alcoholic liver disease. We have recently identified a two signals pathway consisting of activation of TLR9 by DNA from apoptotic self cells, and also activation of the inflammasome pathway. In addition we have found that the cheap and safe anti-inflammatory drug aspirin can inhibit the TLR9 mediated pathway. We are expanding these findings to test their general applicability to a wide range of liver diseases and also to further identify the role of up-stream activating steps including nuclear DNA, and metabolites of the uric acid pathway.
Specialized Terms: Non-alcoholic hepatitis, Sterile inflammation; Liver fibrosis; Liver immunology
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论文共 93 篇作者统计合作学者相似作者
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Science China Life Sciencespp.1-15, (2024)
Frhaan M. Zahrawi,Wajahat Z. Mehal
Hepatology (Baltimore, Md.)no. 5 (2024): E129-E129
Soum D. Lokeshwar,Ather Ali,Theresa R. Weiss,Jesse Reynolds,Brian M. Shuch, Thomas Ferencz, Tassos C. Kyriakides,Wajahat Z. Mehal,Joseph Brito,Joseph Renzulli,Michael S. Leapman
BMC Urologyno. 1 (2024): 1-8
JCI INSIGHTno. 9 (2024)
Suyavaran Arumugam,Binghua Li, Sri Lakshmi Tejaswi Boodapati,Michael H. Nathanson,Beicheng Sun,Xinshou Ouyang,Wajahat Z. Mehal
HEPATOLOGYno. 5 (2023): 1448-1461
AMERICAN JOURNAL OF GASTROENTEROLOGYno. 10 (2023): S1193-S1194
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#Papers: 94
#Citation: 5628
H-Index: 34
G-Index: 67
Sociability: 6
Diversity: 3
Activity: 16
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