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Hepatitis B virus (HBV) chronically infects hepatocytes, the major parenchymal cell of the liver. Hepatocytes represent a long-lived, self-replenishing population in the healthy liver. If the immune system fails to clear the infection within a few months, individuals usually remain infected for life. Chronic infections lead to chronic liver injury, cirrhosis and hepatocellular carcinoma (HCC). The primary cause of these diseases is the injury caused by the antiviral immune response to infected hepatocytes, as infection per se does not appear to be cytotoxic. The goal of ongoing research is to test the hypothesis that chronic immune killing of infected hepatocytes selects for clonal expansion of hepatocytes that have lost the ability to support HBV replication. Clonal hepatocyte repopulation of the liver is an HCC risk factor.
Hepatitis B virus (HBV) chronically infects hepatocytes, the major parenchymal cell of the liver. Hepatocytes represent a long-lived, self-replenishing population in the healthy liver. If the immune system fails to clear the infection within a few months, individuals usually remain infected for life. Chronic infections lead to chronic liver injury, cirrhosis and hepatocellular carcinoma (HCC). The primary cause of these diseases is the injury caused by the antiviral immune response to infected hepatocytes, as infection per se does not appear to be cytotoxic. The goal of ongoing research is to test the hypothesis that chronic immune killing of infected hepatocytes selects for clonal expansion of hepatocytes that have lost the ability to support HBV replication. Clonal hepatocyte repopulation of the liver is an HCC risk factor.
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VIRUSES-BASELno. 2 (2021): 210
The Liverpp.793-820, (2020)
Lars Magnius,John Taylor,William S Mason,Camille Sureau,Paul Dény,Helene Norder, Ictv Report Consortium
Molecular and Translational MedicineHepatitis B Virus in Human Diseasespp.123-145, (2016)
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