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Our research objectives are to understand the cellular mechanisms involved in the development and maintenance of epithelial cell polarity. Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs. Recent studies indicate that the development of epithelial cell polarity is a multistage process requiring instructive extracellular cues (eg. cell-cell and cell-substratum contact) and the reorganization of proteins in the cytoplasm and on the plasma membrane. Once established, polarity is maintained by targeting and retention of proteins to functionally distinct apical and basal-lateral plasma membrane domains.
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Papers共 360 篇Author StatisticsCo-AuthorSimilar Experts
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Cellular and Molecular Bioengineeringno. 6 (2021): 661-662
Cellno. 22 (2021): 5635-5652.e29
JOURNAL OF MICROMECHANICS AND MICROENGINEERINGno. 12 (2020): 125004
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