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Bio
For over 30 years, I have been fortunate enough to deliver key contributions towards our understanding of the organization and molecular composition of the innate immune response. My research activities comprise molecular biology, gene regulation, protein biosynthesis, structural biology, structure/function relations, measurements of functional activities, systems cross-talk, establishment of gene-targeted and transgenic mouse lines and their phenotypic characterisation in experimental models of disease. One of my key achievements over the recent years was my part in the discovery of a novel activation pathway of complement, now known as the lectin pathway. My work has led to the discovery of pathophysiological processes driven and maintained by dysregulation of this specific activation pathway linked to a plethora of chronic inflammatory human and animal diseases. This work was made possible through major funding support from both the MRC and the WELLCOME TRUST at programme grant level.
Research Interests
Papers共 242 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of Neuroinflammationno. 1 (2024): 1-11
Frontiers in immunology (2023): 1192767-1192767
Scandinavian journal of immunologyno. 4 (2023)
CLINICAL AND TRANSLATIONAL MEDICINEno. 7 (2022): n/a-n/a
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#Papers: 242
#Citation: 10525
H-Index: 61
G-Index: 96
Sociability: 7
Diversity: 3
Activity: 31
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