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In addition, we worked on two human breast cancer susceptibility genes, BRCA1 & BRCA2 and have established their dual participation in transcription regulation and DNA damage repair. BRCA1 has been shown to associate directly with the RAD50/MRE11/NBS1 complex, which functions in both non-homologous end-joining and homologous recombination repair of DNA double-strand breaks. The BRCA2 via its BRC repeats binds to RAD51, which catalyzes homologous DNA pairing and DNA strand exchange in an in vitro recombination reaction. Expression of a wild-type BRC repeat disrupted this interaction and rendered cells hypersensitive to gamma-irradiation and failed to activate the G2/M checkpoint. Small molecules that disrupt the interaction between BRC repeat and Rad51 have been isolated. These small compounds offer a potential to develop new combinatorial treatment with chemotherapy or radiation therapy.
Research Interests
Papers共 237 篇Author StatisticsCo-AuthorSimilar Experts
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Sui-Chih Tien,Chin-Chun Chang, Ching-Hsuan Huang,Hsuan-Yu Peng,Yu-Ting Chang,Ming-Chu Chang,Wen-Hwa Lee, Chun-Mei Hu
iScienceno. 7 (2024): 110346
British Journal of Cancerno. 7 (2024): 1-13
Sui-Chih Tien,Chin-Chun Chang,I-Chih Chen, Ching-Hsuan Huang,Hsuan-Yu Peng,Yu-Ting Chang,Ming-Chu Chang,Chun-Mei Hu,Wen-Hwa Lee
Cancer Researchno. 6_Supplement (2024): 459-459
crossref(2023)
crossref(2023)
crossref(2023)
R. L. Becerra,A. Klotz,J. L. Atteia,D. Guetta,A. M. Watson,F. De Colle, C. Angulo-Valdez,N. R. Butler,S. Dichiara,N. Fraija, K. Garcia-Cifuentes,A. S. Kutyrev,
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETYno. 3 (2023): 3262-3273
crossref(2023)
Advanced science (Weinheim, Baden-Wurttemberg, Germany)no. 36 (2023): e2301240-e2301240
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Author Statistics
#Papers: 238
#Citation: 21932
H-Index: 66
G-Index: 146
Sociability: 7
Diversity: 3
Activity: 43
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