基本信息
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Career Trajectory
Bio
Dr. Symmans’ defining contributions to the field of breast cancer include an improved method to measure pathologic response, and the development of genomic assays to predict both response and survival following neoadjuvant chemotherapy. Within 5 years of initial publication, the residual cancer burden (RCB) method of pathologic evaluation has become a standard secondary or primary response endpoint in clinical trials (e.g. the online RCB calculator website had 17,000 visits in 2011). RCB has also formed a basis for training more effective chemopredictive genomic assays that consider primary resistance separately from excellent response, and for understanding the sequential synergy that can be achieved with chemo-endocrine therapy for Stage II-III breast cancer. These findings are re-shaping the approach to development of “omics-based” predictive tests. In parallel, he has advanced the practical application of minimally invasive breast biopsy techniques for translational research through evidence-based studies of biospecimen yield and quality.
Research Interests
Papers共 776 篇Author StatisticsCo-AuthorSimilar Experts
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Chowdhury Arif Jahangir,David B. Page,Glenn Broeckx, Claudia A. Gonzalez, Caoimbhe Burke, Clodagh Murphy,Jorge S. Reis-Filho,Amy Ly,Paul W. Harms,Rajarsi R. Gupta,Michael Vieth,Akira Hida,
JOURNAL OF PATHOLOGYno. 3 (2024): 271-288
Clinical cancer research : an official journal of the American Association for Cancer Researchno. 4 (2024): 729-740
Frederique Madeleine Penault-Llorca,Amelie Lusque, Thomas Filleron,Kevin Tran,Lili Du,Frederick Baehner,Florence Dalenc,Magali Lacroix-Triki,Thomas Bachelot,Fabrice Andre, Pascal Boucher,Jerome Lemonnier,
Journal of Clinical Oncologyno. 16_suppl (2024): 565-565
CANCER RESEARCHno. 3 (2024)
Histopathologyno. 7 (2024): 1111-1129
Mark Jesus M. Magbanua,Ziad Ahmed,Rosalyn W. Sayaman,Lamorna Brown Swigart, Gillian L. Hirst, Christina Yau, Denise M. Wolf, Wen Li,Amy L. Delson, Jane Perlmutter, Paula Pohlmann,W. Fraser Symmans,
crossref(2024)
Journal of Clinical Oncologyno. 16_suppl (2024): 538-538
Mark Jesus M. Magbanua,Ziad Ahmed,Rosalyn W. Sayaman,Lamorna Brown Swigart, Gillian L. Hirst, Christina Yau, Denise M. Wolf, Wen Li,Amy L. Delson, Jane Perlmutter, Paula Pohlmann,W. Fraser Symmans,
crossref(2024)
Cancerno. 10 (2024): 1747-1757
Amy Jo Chien,Rita A. Mukhtar,Karthik Giridhar,Olufunmilayo I. Olopade,Kevin Kalinsky,Christos Vaklavas, Anthony D. Elias, Mei Wei,Matthew P. Goetz, Laura van 't Veer,Silver Alkhafaji,Hope S. Rugo,
Journal of Clinical Oncologyno. 16_suppl (2024): 601-601
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