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Elucidating the mechanisms of cell fate determination
Mammals have evolved a myriad of methods by which diverse tissues are specified, develop, and then are maintained by stem cells. Our lab is focused on the transcriptional mechanisms that underlie each of these processes to not only understand development, but also cancer, where these processes go awry. Our lab uses human pluripotent stem cells to model the acquisition of cell fate early in the embryo, and adult mice to model the de-differentiation that is the basis for cancer formation.
Elucidating the mechanisms of cell fate determination
Mammals have evolved a myriad of methods by which diverse tissues are specified, develop, and then are maintained by stem cells. Our lab is focused on the transcriptional mechanisms that underlie each of these processes to not only understand development, but also cancer, where these processes go awry. Our lab uses human pluripotent stem cells to model the acquisition of cell fate early in the embryo, and adult mice to model the de-differentiation that is the basis for cancer formation.
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论文共 77 篇作者统计合作学者相似作者
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C. Galvan,Aimee Flores, Victoria Cerillos, Itzetl Avila,Conor Murphy, Wenwen Zheng,Teng Teng To,Heather R. Christofk,William E. Lowry
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Neuronno. 18 (2022): 2929-2948.e8
Matilde Miranda, Itzetl Avila, Jasmine Esparza,Yulia Shwartz,Ya-Chieh Hsu,Rebecca Berdeaux,William E Lowry
Irene L Llorente,Yuan Xie,Jose A Mazzitelli, Emily A Hatanaka,Jessica Cinkornpumin, David R Miller,Ying Lin,William E Lowry,S Thomas Carmichael
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