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职业迁徙
个人简介
The connections between autophagy and tuberculosis began with Dr. Deretic’s seminal publication on the role of autophagy in control of Mycobacterium tuberculosis (Mtb) published in Cell in 2004. This was followed by sustained development of the filed including Dr. Deretic’s publications in Science 2006, Nature Cell Biology 2010, a series of studies in Immunity, and more recent studies in 2015-2017 published in Molecular Cell, JCB, Developmental Cell, EMBO J, etc. Dr. Deretic has been consistently invited to summarize the new field of autophagy as an innate immunity and anti-inflammatory process as exemplified in the earliest reviews on this topic in 2005 and most recently in Nature Reviews Immunology (2013), JCI (2015) J. Exp. Med. (2015), and JLB (2016). His group reported a broad role of proteins termed TRIMs (82 members in humans) as autophagic regulator-receptors, published in a series articles in Developmental Cell (2014, 2016) J. Cell Biol. (2015), etc. Dr. Deretic’s lab reported on the role of specific SNAREs in controlling how autophagy terminates - in secretion (EMBO J 2017) or degradation (J. Cell Biol, 2018). Most recently, Dr. Deretic and colleagues have uncovered the role of cytosolic lectins, termed galectins, in direct control of mTOR and AMPK, the most upstream regulators of autophagy and master regulators of cellular metabolism (Molecular Cell, 2018). In terms of translational efforts, Dr. Deretic’s group has identified a series of potential therapeutics aimed at autophagy, ready for repurposing (Nature Comm., 2015; and US patent 9572820). Dr. Deretic was 2012 Chair of Gordon Research Conference on Autophagy, and will be the lead organizer/chair of the 2019 Keystone Symposium on Autophagy.
研究兴趣
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Masroor Ahmad Paddar,Fulong Wang, Einar S Trosdal,Emily Hendrix, Yi He,Michelle Salemi,Michal Mudd,Jingyue Jia,Thabata L A Duque,Ruheena Javed,Brett Phinney,Vojo Deretic
bioRxiv : the preprint server for biology (2024)
Nature Cell Biologyno. 3 (2024): 307-308
AUTOPHAGYno. 2 (2024): 448-450
The EMBO journalno. 14 (2023): e112845-e112845
Nature Microbiologyno. 5 (2023): 762-763
Frontiers in tuberculosis (2023)
Developmental cellno. 10 (2023): 866-884.e8
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