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The focus of my research group is to understand the immune mechanisms involved in chronic inflammatory eye diseases, in order to improve therapeutic strategies. Currently steroids and cyclosporin are the mainstay immunosuppressive for treating the chronic inflammatory diseases of the retina (uveitis) and ocular surface (chronic allergic eye disease, ketaroconjunctivitis sicca). Although they can be effective in dampening the inflammation, these drugs can have serious side-effects in the eye including cataract formation and glaucoma. There is therefore a need for localised treatment to intervene on the specific immune pathways involved in this diverse range of clinical situations.
The role of effector CD4+T cell subsets and their cytokines has been investigated in experimental models and in human tissues, fluids and tissue-derived cell populations.The different porportions of TH1, TH2 and TH17 subsets, and their cytokine profiles, is a likely explanation for the varied responses of individuals to therapies, and the range of clinical severities in each subtype of disease.
We are now focussing on applying novel anti-inflammatory agents to the experimental model of uveitis, in collaboration with GSK, and in several in vitro models of ocular allergy, in collaboration with Allergan Inc., and are developing a range of experimental models of ocular allergy. The relative contribution of each cytokine will be investigated in an attempt to further unravel the molecular mechanisms involved in each subtype of ocular disease.
The focus of my research group is to understand the immune mechanisms involved in chronic inflammatory eye diseases, in order to improve therapeutic strategies. Currently steroids and cyclosporin are the mainstay immunosuppressive for treating the chronic inflammatory diseases of the retina (uveitis) and ocular surface (chronic allergic eye disease, ketaroconjunctivitis sicca). Although they can be effective in dampening the inflammation, these drugs can have serious side-effects in the eye including cataract formation and glaucoma. There is therefore a need for localised treatment to intervene on the specific immune pathways involved in this diverse range of clinical situations.
The role of effector CD4+T cell subsets and their cytokines has been investigated in experimental models and in human tissues, fluids and tissue-derived cell populations.The different porportions of TH1, TH2 and TH17 subsets, and their cytokine profiles, is a likely explanation for the varied responses of individuals to therapies, and the range of clinical severities in each subtype of disease.
We are now focussing on applying novel anti-inflammatory agents to the experimental model of uveitis, in collaboration with GSK, and in several in vitro models of ocular allergy, in collaboration with Allergan Inc., and are developing a range of experimental models of ocular allergy. The relative contribution of each cytokine will be investigated in an attempt to further unravel the molecular mechanisms involved in each subtype of ocular disease.
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MULTIPLE SCLEROSIS JOURNAL (2023): 842-843
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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BMJ OPEN OPHTHALMOLOGYno. 1 (2022): e001040-e001040
Clare Mills,Sandra A Hemkemeyer, Zerin Alimajstorovic,Chantelle Bowers,Malihe Eskandarpour,John Greenwood,Virginia Calder,A W Edith Chan,Paul J Gane, David L Selwood,Karl Matter,Maria S Balda
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