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Haematopoietic stem cells (HSC) provide a lifelong supply of blood and immune cells. While they continuously produce specialised cells, they also replenish a pool of stem cells in the bone marrow, a property known as self-renewal. Thanks to this property, bone marrow or cord blood transplantation provide a life-saving treatment for blood and immune-related diseases. Unfortunately, donor-matching or insufficient number of cells still render these therapies unfeasible or unsuccessful for certain patients.
Attempts to overcome these limitations have been unable to create or expand in a dish a reliable source of blood stem cells for patients, mostly because of defective self-renewal. Our research focuses on understanding the establishment and maintenance mechanisms that endow human HSC self-renewal, as determined by the expression of specific genes sets that define HSC function. We investigate the regulation of the expression of such HSC-defining genes, how the environment and the metabolism affect this regulation, and how attempts to make or maintain these cells in vitro can be improved to preserve their stemness. By gaining a better understanding of HSC biology, our studies aim to contribute to the development of novel HSC-based therapies.
Haematopoietic stem cells (HSC) provide a lifelong supply of blood and immune cells. While they continuously produce specialised cells, they also replenish a pool of stem cells in the bone marrow, a property known as self-renewal. Thanks to this property, bone marrow or cord blood transplantation provide a life-saving treatment for blood and immune-related diseases. Unfortunately, donor-matching or insufficient number of cells still render these therapies unfeasible or unsuccessful for certain patients.
Attempts to overcome these limitations have been unable to create or expand in a dish a reliable source of blood stem cells for patients, mostly because of defective self-renewal. Our research focuses on understanding the establishment and maintenance mechanisms that endow human HSC self-renewal, as determined by the expression of specific genes sets that define HSC function. We investigate the regulation of the expression of such HSC-defining genes, how the environment and the metabolism affect this regulation, and how attempts to make or maintain these cells in vitro can be improved to preserve their stemness. By gaining a better understanding of HSC biology, our studies aim to contribute to the development of novel HSC-based therapies.
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Nature Communicationsno. 1 (2024): 1-11
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Experimental Hematology (2022): S43-S43
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Experimental Hematology (2022): S32
Elizabeth Ng, Jacky Li,Ritika Saxena, Hasindu Edirisinghe, Gulcan Sarila,Freya Bruveris,Shicheng Sun,Tanya Labonne,Vincenzo Calvanese,Sandra Capellera-Garcia,Feiyang Ma,Hanna Mikkola,
Experimental Hematology (2022): S38
J. Aguade-Gorgorio,Y. Jami-alahmadi, M. Kardouh,I. Fares,V. Calvanese, H. Johnson,M. Magnusson, J. Shin, H. Goodridge,J. Wohlschlegel,H. Mikkola
Experimental Hematology (2022): S126-S126
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