基本信息
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Career Trajectory
Bio
During the first part of my carreer, I focused my research on post-transcriptional controls of gene expression during embryonic development. I have characterized the role of the RNA-binding protein CELF1 (previously known as EDEN-BP) in regulating the polyadenylation state, translation and stability of maternal mRNAs in amphibian embryos.
Among the maternal mRNAs controlled by CELF1, I focused my attention on one encoding pEg7/NCAPD2, a non-SMC subunit of the Condensin complex. I have shown that NCAPD2 plays a crucial role in the dynamics of both meiotic and mitotic chromosomes. Beside this, I showed in collaboration with Raphael Métivier, that Cohesin (a complex related to Condensin) is required for the spatial remodeling of the genome upon transcriptional response to estrogens.
More recently, I studied the role of CELF1 in later developmental stages and in tissue homeostasis. Celf1_KO mice exhibit a severe cataract and, based on this finding, I was involved in a project aiming to decipher the role of CELF1 in lens, in collaboration with the Salil Lachke's group (University of Delawware). Beyond this collaborative work, I have identified by RNA-seq the mRNAs whose expression is controlled by CELF1 in lens, and more specifically those regulated at the level of pre-mRNA splicing.
In 2016, I joined the team leaded by Nathalie Theret, whose aim is to decipher the role of adamalysins and other extracellular matrix proteins in the control of TGF-β signaling and progression of chronic liver diseases (Fibrosis and Cellular Hepatocarcinoma). For this project, we implement complementary approaches such as cell biology, biochemistry, functional genomics, system biology and modeling.
More recently, these developments led me to create and coordinate a 3D bioprinting and microfluidic platform (BIM3D), homed by the Rennes federation of facilities (Biosit) and managed by Laurent Griscom, a research engineer at the CNRS.
Research Interests
Papers共 54 篇Author StatisticsCo-AuthorSimilar Experts
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Bassil Dekky,Fida Azar,Dominique Bonnier,Christine Monseur, Chiara Kalebic, Esther Arpigny,Alain Colige,Vincent Legagneux,Nathalie Theret
The FASEB journalno. 11 (2023)
Marie Cuvellier,Sophie Rose,Frédéric Ezan,Ulrich Jarry,Hugo de Oliveira,Arnaud Bruyère, Christophe Drieu La Rochelle,Vincent Legagneux,Sophie Langouët,Georges Baffet
Biomaterials (2020): 120611-120611
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Author Statistics
#Papers: 54
#Citation: 1385
H-Index: 23
G-Index: 36
Sociability: 5
Diversity: 3
Activity: 11
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