基本信息
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职业迁徙
个人简介
Research Abstract
My current research interests are focused on 3 key aspects of skeletal muscle: i) the mechanistic role of contractile and regulatory proteins in muscle mechanics; ii) the mechanistic basis of muscle plasticity; and iii) the application of the first two pursuits to clinically relevant pathologies.
Regarding the first area, previous studies conducted in my laboratory have focused upon the relationship between myosin isoforms and maximal shortening velocity. Current studies are directed at a more complete understanding of the role of myosin using whole muscle, single motor unit, and single fiber studies. Using the novel work loop technique, I have been able to develop a model that describes the role of activation and relaxation processes in limiting the mechanical work produced by skeletal muscle during repetitive contractions. These studies have shown that relaxation plays a major role in limiting the amount of mechanical work that can be produced by skeletal muscle, and that relaxation is length and strain dependent. Future studies with single fibers will specifically focus upon the role of myosin, troponin-C , and the sarcoplasmic reticulum in the relaxation process by using caged chelators of calcium that are activated by laser flash photolysis.
研究兴趣
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Rod Carlo Columbres, Hua Yu,Saya Horiuchi, Tang Bao-pen, Yue Chin, Mathew Gargus,Abhilasha Surampalli,Vincent J. Caiozzo,Hiroshi Yoshioka,Virginia Kimonis
Research Square (Research Square) (2023)
Handbook of Bioastronauticspp.165-180, (2021)
Encyclopedia of Bioastronauticspp.1-14, (2019)
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