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个人简介
Vincent David is a CNRS researcher at the Institut de Neuroscience Cognitives et Intégratives d’Aquitaine (INCIA), CNRS UMR 5287 - University of Bordeaux. He received M.S. degrees in Physiology and in Experimental Psychology, and obtained a PhD in Neuroscience and Neuropharmacology at the University of Bordeaux (1998). He completed postdoctoral work at the Scripps Research Institute in San Diego, with George F. Koob and Lisa H. Gold (1998-2001). Recruited by the CNRS in 2001, he centred his research activity on neuronal and molecular mechanisms underlying the addictive properties of abused drugs, reward learning and the long-term impact of drugs of abuse on memory processes. He is currently investigating molecular mechanisms participating to the addictive properties of abused drugs using mouse models of drug self-administration in genetically-engineered strains, lentiviral vectors that are microinjected directly into specific brain areas in the mouse, and more recently optogenetics. Vincent David has received several awards and has contributed to a highly cited Nature paper which recently entered the top 1% of its field (Neuroscience). Key achievements include the demonstration of respective roles of VTA mu- and delta opioid receptors in opiate reward and VTA α4β2, α6*-, α7*-nicotinic cholinergic receptors in the addictive properties of nicotine, the requirement of co-activation of VTA DA and GABAergic neurons for nicotine-induced burst firing of VTA-DA neurons and habit-forming effects. In parallel with this work, Vincent David is interested in how drugs of abuse modulate interactions between multiple memory systems, as well as how systems memory systems modulate drug-seeking behavior. He showed that drug and food rewards elicit the selection of different learning strategies and circuits (respectively striatal or hippocampal-centered), which are maintained by region-dependent CREB activity and related synaptic plasticity. These results open new perspectives on therapeutic interventions against addictive behaviors.
研究兴趣
论文共 50 篇作者统计合作学者相似作者
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Physical review lettersno. 8 (2024): 085201-085201
Frontiers in psychiatry (2023): 1129030
Alina Lakosa, Anaïs Rahimian,Flavio Tomasi,Fabio Marti,Lauren M Reynolds,Léa Tochon,Vincent David,Anne Danckaert, Candice Canonne, Sylvana Tahraoui,Fabrice de Chaumont,Benoît Forget,
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#Papers: 50
#Citation: 1776
H-Index: 21
G-Index: 38
Sociability: 5
Diversity: 3
Activity: 10
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