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个人简介
At different stages of my career I have studied various aspects of human immunodeficiency virus (HIV) and Epstein Barr virus (EBV) infection. My doctoral thesis work focused on the study of the evolution of HIV-1 and the restoration of the mutant reverse transcriptase function of HIV-1 and the replicative capacity by compensatory mutations. Working on these projects I gained a solid background in phylogenetic analysis, in vitro competition experiments, and the dynamics necessary for the selection of antiretroviral drug resistant mutants. After obtaining my PhD, I moved to Boston (USA) to the group of Dr. Gottlinger (Harvard Medical School) for a postdoctoral stay. During this period in Dr. Gottlinger's laboratory I studied new interactions HIV-1, HIV-2, and SIV p6 with cellular proteins. In this project I extended my experience in virology and molecular biology and became familiar with techniques based on protein-protein interactions. After my postdoctoral experience at Harvard, I moved to the University of Massachusetts School of Medicine (USA), where I joined Dr. Katherine Luzuriaga's group. During those years I worked in his laboratory, first as "Research Associate" and later as "Instructor of Pediatrics". I focused on the study of specific responses by cytotoxic CD8 + T lymphocytes in vertical transmission of HIV and their potential role in the evolution of the viral quasispecies. Working on these HIV and EBV related projects, I applied my knowledge in molecular virology and gained a strong background in cellular immunology. Later, I returned to Spain and joined the AIDS Research Unit of the Hospital Clínico-IDIBAPS Barcelona. My research as principal investigator of the Humoral Immunology group and design of a preventive vaccine against HIV at the Laboratory of Retrovirology and Viral Immunopathogenesis (IDIBAPS / Hospital Clinic), involved the isolation and characterization of new neutralizing antibodies to HIV-1 and the optimization as an HIV-1 envelope protein immunogen. Currently, I continue working in both lines as co-principal investigator in the AIDS Immunopathology group of the Carlos III Health Institute.
After more than 20 years of career, my professional experience could be summarized as:
a) Principal investigator of the group of Humoral Immunology and Design of a Preventive Vaccine against HIV (IDIBAPS)
b) Publication of 28 scientific documents.
c) Presentation of 43 papers in national and international conferences
d) Obtaining four scholarships in competitive competition
e) Participation in 15 research projects (9 international and 6 national) Principal Investigator of three national projects
f) Industrial and intellectual property; 1 Invention patent at the level of the European Union and in 15 extra-community countries
g) Direction of 3 doctoral theses and 4 final Master's projects (TFM)
h) Academic mentoring of 5 students (graduate level, USA)
i) Professor in the Master in Biomedicine (UB) and in the Master in treatment and pathogenesis of AIDS (UAB)
j) Collaborations with national and international groups
k) Member of R&D networks (EHVA, RIS, HIVACAT)
l) Reviewer of scientific articles, European projects and member of the scientific committee
研究兴趣
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VACCINESno. 1 (2024)
Vaccinesno. 1 (2023): 8
Scientific reportsno. 1 (2020): 1902-1902
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