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个人简介
In the last 15 years our research has been focused on the development of methods of characterising the structure, dynamics and interactions of proteins in previously inaccessible states. These methods are based on the use of experimental data, in particular from nuclear magnetic resonance spectroscopy, as structural restraints in molecular dynamics simulations. Through this approach it is possible to obtain information about a variety of protein conformations, as for example those populated during the folding process, and about protein interactions in complex environments, including those generating aggregate species that are associated with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.
Application to neurodegenerative diseases
More recently, these studies have led us to investigate the physico-chemical principles of proteins homeostasis and their application to the development of therapeutic strategies against neurodegenerative diseases. Starting from the observation that proteins are expressed in the cell at levels close to their solubility limits, we are developing approaches to prevent or delay misfolding disorders based on the enhancement of our quality control mechanisms against protein aggregation.
Application to neurodegenerative diseases
More recently, these studies have led us to investigate the physico-chemical principles of proteins homeostasis and their application to the development of therapeutic strategies against neurodegenerative diseases. Starting from the observation that proteins are expressed in the cell at levels close to their solubility limits, we are developing approaches to prevent or delay misfolding disorders based on the enhancement of our quality control mechanisms against protein aggregation.
研究兴趣
论文共 786 篇作者统计合作学者相似作者
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Cristina Olivieri,Yingjie Wang,Caitlin Walker, Manu V. Subrahmanian, Kim N. Ha,David A. Bernlohr,Jiali Gao,Carlo Camilloni,Michele Vendruscolo,Susan S. Taylor,Gianluigi Veglia
crossref(2024)
Samuel T Dada,Zenon Toprakcioglu,Mariana P Cali, Alexander Röntgen,Maarten C Hardenberg, Owen M Morris, Lena K Mrugalla,Tuomas P J Knowles,Michele Vendruscolo
Nature communicationsno. 1 (2024): 3835-3835
COMMUNICATIONS BIOLOGYno. 1 (2024)
Rebecca Andrews, Bin Fu,Christina E. Toomey, Jonathan C. Breiter,Joanne Lachica, Ru Tian, Joseph S. Beckwith,Lisa-Maria Needham, Gregory J. Chant, Camille Loiseau, Angèle Deconfin, Kenza Baspin,
biorxiv(2024)
Robert I. Horne, Jared Wilson-Godber, Alicia Gonzalez Diaz,Z. Faidon Brotzakis,Srijit Seal, Rebecca C. Gregory,Andrea Possenti,Sean Chia,Michele Vendruscolo
JOURNAL OF CHEMICAL INFORMATION AND MODELINGno. 3 (2024): 590-596
Sean Chia,Rodrigo Lessa Cataldi, Francesco Simone Ruggeri,Ryan Limbocker, Itzel Condado-Morales,Katarina Pisani,Andrea Possenti, Sara Linse,Tuomas P. J. Knowles,Johnny Habchi,Benedetta Mannini,Michele Vendruscolo
ACS CHEMICAL NEUROSCIENCEno. 6 (2024): 1125-1134
Davide Mazzali, Gabriela Rath, Alexander Röntgen,Vaidehi Roy Chowdhury,Michele Vendruscolo,Marina Resmini
crossref(2024)
Tommaso Amico, Samuel Dada, Andrea Lazzari, Michaela Brezinova,Antonio Trovato,Michele Vendruscolo,Monika Fuxreiter,Amos Maritan
biorxiv(2024)
Bin Fu, Emma E. Brock, Rebecca Andrews, Jonathan C. Breiter, Ru Tian,Christina E. Toomey,Joanne Lachica,Tammaryn Lashley,Mina Ryten,Nicholas W. Wood,Michele Vendruscolo,Sonia Gandhi,
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