基本信息
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职业迁徙
个人简介
• Experimental biologist with over 16 years of basic and translational research in T cell immunity, hematopoietic stem cell transplantation, adoptive cell therapy and other forms of immunotherapy.
• Leading a team of 6 individuals, conducting functional studies using in-vitro, ex-vivo and murine in-vivo models to identify novel approaches to enhance immune recovery in cancer patients
• Collaborated with multidisciplinary teams in the field of hematopoietic stem cell transplant, inflammation, CAR T cells, intestinal microbiota, GVHD, and checkpoint blockade
• Established close integration and internal pipelines between the research laboratory and clinical side to compressively monitor patients' immune response to cancer immunotherapy.
Research focus
My research is primarily focused on characterizing new approaches to enhance hematopoietic regeneration after insults and to identify strategies to boost thymus and T cell function in cancer patients.
Specific Skills
- Preclinical models: Extensive knowledge of hematopoietic stem cell transplant immunobiology and in vivo models to assess immune function.
- Flow Cytometry: Expert in designing and performing advanced multiparametric flow cytometry experiments, especially for patient immune monitoring. Proficient in phenotyping immune and non-immune cells.
- Molecular and Cell Biology: Expert in DNA/RNA/protein analysis
- Immune assays: Expertise in the manipulation of T cells and identify optimal functional assays.
Optimal recovery of hematopoietic function is a critical process in several clinical situations such as after cytoreductive chemo- or radiation therapy, infection, shock, as well as after radiation injury. Prolonged immune suppression has consequences at multiple levels including increased opportunistic infections, malignant relapse, morbidity and mortality. Therefore, development of strategies to improve the regeneration of hematopoietic system and reconstitution of the peripheral T cell pool represents a significant clinical challenge with the potential to improve overall outcome in immunocompromised recipients.
Awards
Amy Strelzer Manasevit Research Program Award (2018)
ASH Abstract Achievement Award (58th ASH Annual Meeting in San Diego, CA) (2016)
Immunology and Microbial Pathogenesis (IMP) Scientific Retreat Publication Award (2015)
AAI Trainee Abstract Award (The American Association of Immunologists Annual Meeting – New Orleans, LA) (2015)
ASH Abstract Achievement Award (55th ASH Annual Meeting), New Orleans, LA (2014)
American Society for Blood and Marrow Transplantation New Investigator Award (2013)
Italian Foundation for Cancer Research Award for Abroad Research (2011)
Italian Society of Pharmacology Award for Abroad Research (2011)
• Leading a team of 6 individuals, conducting functional studies using in-vitro, ex-vivo and murine in-vivo models to identify novel approaches to enhance immune recovery in cancer patients
• Collaborated with multidisciplinary teams in the field of hematopoietic stem cell transplant, inflammation, CAR T cells, intestinal microbiota, GVHD, and checkpoint blockade
• Established close integration and internal pipelines between the research laboratory and clinical side to compressively monitor patients' immune response to cancer immunotherapy.
Research focus
My research is primarily focused on characterizing new approaches to enhance hematopoietic regeneration after insults and to identify strategies to boost thymus and T cell function in cancer patients.
Specific Skills
- Preclinical models: Extensive knowledge of hematopoietic stem cell transplant immunobiology and in vivo models to assess immune function.
- Flow Cytometry: Expert in designing and performing advanced multiparametric flow cytometry experiments, especially for patient immune monitoring. Proficient in phenotyping immune and non-immune cells.
- Molecular and Cell Biology: Expert in DNA/RNA/protein analysis
- Immune assays: Expertise in the manipulation of T cells and identify optimal functional assays.
Optimal recovery of hematopoietic function is a critical process in several clinical situations such as after cytoreductive chemo- or radiation therapy, infection, shock, as well as after radiation injury. Prolonged immune suppression has consequences at multiple levels including increased opportunistic infections, malignant relapse, morbidity and mortality. Therefore, development of strategies to improve the regeneration of hematopoietic system and reconstitution of the peripheral T cell pool represents a significant clinical challenge with the potential to improve overall outcome in immunocompromised recipients.
Awards
Amy Strelzer Manasevit Research Program Award (2018)
ASH Abstract Achievement Award (58th ASH Annual Meeting in San Diego, CA) (2016)
Immunology and Microbial Pathogenesis (IMP) Scientific Retreat Publication Award (2015)
AAI Trainee Abstract Award (The American Association of Immunologists Annual Meeting – New Orleans, LA) (2015)
ASH Abstract Achievement Award (55th ASH Annual Meeting), New Orleans, LA (2014)
American Society for Blood and Marrow Transplantation New Investigator Award (2013)
Italian Foundation for Cancer Research Award for Abroad Research (2011)
Italian Society of Pharmacology Award for Abroad Research (2011)
研究兴趣
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