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The focus of Dr. Papadopoulos’ research is in the pathophysiology and treatment of diseases related to altered steroid hormone synthesis, including endocrine pathologies, male reproductive disorders, neuropathologies, and cancer. His work has led to better understanding of steroidogenesis in testis and brain, and to the identification of the molecular basis of diseases in which steroids play a determining role. He has used biochemical, pharmacological, cellular and molecular methods as well as in vitro and in vivo functional studies in animal models to study the structure and function of proteins involved in cholesterol movement into mitochondria. His laboratory has shown that there is a common, fundamental and conserved mechanism of cholesterol import into mitochondria that dictates the rate of steroid formation. This has led to the understanding that changes in this mechanism could lead to tissue-specific pathologies and disease-modifying therapies. During these studies his laboratory developed new methods, and generated intellectual property and materials that were distributed to academic and pharmaceutical laboratories throughout the world. Moreover, he worked closely with the industry to move concepts from the bench to the bedside.
The focus of Dr. Papadopoulos’ research is in the pathophysiology and treatment of diseases related to altered steroid hormone synthesis, including endocrine pathologies, male reproductive disorders, neuropathologies, and cancer. His work has led to better understanding of steroidogenesis in testis and brain, and to the identification of the molecular basis of diseases in which steroids play a determining role. He has used biochemical, pharmacological, cellular and molecular methods as well as in vitro and in vivo functional studies in animal models to study the structure and function of proteins involved in cholesterol movement into mitochondria. His laboratory has shown that there is a common, fundamental and conserved mechanism of cholesterol import into mitochondria that dictates the rate of steroid formation. This has led to the understanding that changes in this mechanism could lead to tissue-specific pathologies and disease-modifying therapies. During these studies his laboratory developed new methods, and generated intellectual property and materials that were distributed to academic and pharmaceutical laboratories throughout the world. Moreover, he worked closely with the industry to move concepts from the bench to the bedside.
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Sathvika Venugopal,Melanie Galano, Rachel Chan, Esha Sanyal,Leeyah Issop,Sunghoon Lee, Lorne Taylor, Pushwinder Kaur,Edward Daly,Vassilios Papadopoulos
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