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My main scientific research so far focuses on the study of the functions of the CNS in normal and pathological conditions, mainly in the context of Neuroimmunology and neurological diseases. Using experimental models, transgenic animals, confocal and two-photon microscopy, molecular and immunological techniques, bioinformatics and behavioral animal models, I study cell-specific functions of the CNS to identify molecular mechanisms and specialized molecular targets with clinical relevance and/or therapeutic potential against neurodegenerative and other neurological disorders. I have specialized in the study of microglia, the resident immune cells of the brain. During my PhD at HPI I studied the role of microglia in the healthy brain, in learning and memory processes, for the purposes of which I visited a specialized laboratory in Spain and conducted advanced behavioral tests in mice. At a post-doctoral level, at UCL I gained particular expertise in in vivo two-photon microscopy techniques in mice as well as bioinformatic image analysis systems and investigated the mechanisms underlying the highly motile nature of microglia in the healthy and injured brain. I was then awarded with a prestigious Greek fund from H.F.R.I. for independent postdoctoral research at HPI in Athens, during which I supervised a three-member group and applied the new imaging methodologies to investigate microglia mechanisms involved in demyelination and neuroinflammation. First, new bioinformatic systems were developed to analyze the dynamics of microglia during the progression of pathology of MS models, the application of which revealed particular cytological features in the very early stages of the disease, which can be used as clinical prognostic indicators. Second, specialized transgenic systems were developed to dissociate the role of microglia from peripheral macrophages in the development of neuroinflammation, an approach that revealed the specialized role of brain parenchymal microglia, through the action of the transcription factor NF-κB, in neuroinflammation. Currently, I use sophisticated molecular techniques, such as NGS, and develop advanced in vivo bioimaging technologies, such as chronic cranial window to image the evolution of microglia motility in the brain in real time, during the progression of pathology in animal models, with the aim to identify intrinsic mechanisms of the CNS, which remain unknown to date and may have important functions in the pathophysiology of neurodegenerative and other neurological diseases. In March 2023 I started my career as a junior faculty researcher at the Hellenic Pasteur Institute after being elected for a junior faculty research position. My plan is to continue studying microglia in the context of disease, with infectious diseases and neurodevelopmental psychiatric disorders being my most important targets for future investigation.
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Journal of Neuroinflammationno. 1 (2024): 34-34
JOURNAL OF NEUROINFLAMMATIONno. 1 (2024)
V. Kyrargyri, I. Roufagalas, M. Avloniti, A. Fortosi,D. Thomaidou, E. Xingi, L. Probert, V. Kyrargyri
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Proceedings of the National Academy of Sciences of the United States of Americano. 7 (2018): E1608-E1617
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