Varsha Gandhi

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Research Interests 1. Translational research in hematological malignancies 2. Development of single agent and combination therapies for leukemias 3. Transcription inhibitors 4. DNA- and RNA-directed nucleoside analogs, their mechanisms of action and development of resistance 5. Apoptosis modulators as therapeutics (BH3-mimetics, smac-mimetics) 6. Role of microenvironment in hematological malignancies 7. Pim kinase expression and targeting by small molecule inhibitors

Research Interests

Papers共 511 篇Author StatisticsCo-AuthorSimilar Experts

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Inhibition of MCL-1 and MEK Overcomes MEK Inhibitor Resistance in Triple-Negative and Inflammatory Breast Cancers

Mohd Mughees, Moises J Tacam, Alex W Tan, Mary K Pitner,LaKesla R Iles,Xiaoding Hu, Emilly S Villodre,Bisrat G Debeb,Takahiro Kogawa,Bora Lim,Rachel M Layman, Wendy A Woodward, Naoto T Ueno,Debu Tripathy,Savitri Krishnamurthy,Yuan Qi,Lajos Pusztai,Jian Wang,Varsha Gandhi,Geoffrey Bartholomeusz,Chandra Bartholomeusz

Molecular cancer therapeutics (2025)

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A Pilot Study of Lower Doses of Ibrutinib: Patient Body Weight Does Not Correlate with Plasma Ibrutinib Levels During Therapy

Lisa S Chen,Prithviraj Bose,Wei Qiao, Yongying Jiang, Qi Wu,Nichole D Cruz,Michael J Keating,Varsha Gandhi

Leukemia & lymphomano. 6 (2025): 1166-1168

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Pharmacological Profiling in CLL Patients During Pirtobrutinib Therapy and Disease Progression

Varsha Gandhi, Shady Tantawy,Burcu Aslan,Ganiraju Manyam, Lakesla Iles,Natalia Timofeeva, Neetu Singh,Nitin Jain,Alessandra Ferrajoli, Philip Thompson,Keyur Patel, Sai Prasad Desikan, William Wierda

Research square (2025)

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Transcriptomic and Proteomic Differences in BTK-WT and BTK-mutated CLL and Their Changes During Therapy with Pirtobrutinib

Burcu Aslan,Ganiraju Manyam,Lakesla R. Iles,Shady I. Tantawy,Sai Prasad Desikan,William G. Wierda,Varsha Gandhi

Blood Advances (2024)

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The DLEU2/miR-15a/miR-16-1 Cluster Shapes the Immune Microenvironment of Chronic Lymphocytic Leukemia

Ronghua Zhang, Priyanka Khare,Priyanka Banerjee,Cristina Ivan,Sarah Schneider,Federica Barbaglio,Karen Clise-Dwyer,Vanessa Behrana Jensen,Erika Thompson,Marisela Mendoza,Nicholas Chiorazzi,Shih-Shih Chen, Xiao-Jie Joy Yan,Nitin Jain,Paolo Ghia,Federico Caligaris-Cappio, Rima Mendonsa, Sashi Kasimsetty, Ryan Swoboda,Recep Bayraktar,William Wierda,Varsha Gandhi,George A. Calin,Michael J. Keating,Maria Teresa Sabrina Bertilaccio

BLOOD CANCER JOURNALno. 1 (2024)

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Ibrutinib and Venetoclax in Combination for Chronic Lymphocytic Leukemia: Synergy in Practice

Natalia Timofeeva,Nitin Jain,Varsha Gandhi

Blood neoplasiano. 3 (2024)

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Preliminary Results from a Phase 1b Study of Non-Covalent Pan-Mutant BTK Inhibitor Docirbrutinib (AS-1763) in Patients with Previously Treated B-Cell Malignancies

Nitin Jain,Catherine C. Coombs, James D'Olimpio,Nirav N. Shah,Jacqueline C. Barrientos,Seung Tae Lee, Andrew Gillis-Smith,Shuo Ma, Shirou Kirita,Masaaki Sawa,Kyoko Miyamoto,Akinori Arimura,William G. Wierda,Varsha Gandhi,Javier Pinilla-Ibarz

Bloodno. Supplement 1 (2024): 1866-1866

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Transcriptomic Clustering of Chronic Lymphocytic Leukemia: Molecular Subtypes Based on Bruton’s Tyrosine Kinase Expression Levels

Gorkem Kismali,Ganiraju Manyam,Nitin Jain,Cristina Ivan,Betty Lamothe,Mary L. Ayres,LaKesla R. Iles,William G. Wierda,Varsha Gandhi

BLOOD CANCER JOURNALno. 1 (2024)

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Combination of Pirtobrutinib, Venetoclax and Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia (CLL): A Phase II Trial

International Journal of Cancer Care and Delivery (2024)

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Combined Pirtobrutinib, Venetoclax, and Obinutuzumab As First-Line Treatment of Patients with Chronic Lymphocytic Leukemia (CLL)

Bloodno. Supplement 1 (2024): 1011-1011

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Papers共 511 篇Author StatisticsCo-AuthorSimilar Experts