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Our main scientific interest lies in the field of plant-microbe interactions. We are in particularly interested in understanding how pathogen perception leads to reprogramming of gene expression. Through evolution plants have evolved two strategies of pathogen perception, extracellular recognition of pathogen-associated molecular patterns (PAMPs) by trans-membrane pattern recognition receptors (PRRs) and intracellular recognition of effectors by multi-domain resistance (R) proteins. Despite our understanding of how plants perceive pathogens, little is known about the downstream responses leading to reprogramming of gene expression.
Upon pathogen perception, plant cells are faced with the challenge to reallocate their limited resources and quickly change their state of gene transcription with the minimum cost on other biological processes. Chromatin remodelling is now recognized as a major mechanism controlling gene expression and a point of cross talk between different pathways. Chromatin remodelling requires histone covalent modifications and/or the action of ATP-dependent remodelling complexes.
We use the model pathosystem consisting of the host Arabidopsis thaliana and the bacterial pathogen Pseudomonas syringae in combination with genome-wide approaches such as mRNA-seq and ChIP-seq, confocal microscopy and biochemistry to identify how pathogen perception leads to chromatin remodelling that ultimately controls gene expression. An understanding of how chromatin remodelling regulates plant immune responses will be an important step towards engineering plants with durable resistance and increased crop yields.
Research Interests
Papers共 45 篇Author StatisticsCo-AuthorSimilar Experts
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Environmental microbiomeno. 1 (2023): 1-13
Jamie Harrison, Rana Muhammad Fraz Hussain,Shannon F Greer,Vardis Ntoukakis,Andrew Aspin,Joana G Vicente,Murray Grant,David J Studholme
Access microbiologyno. 7 (2023)
Rory Osborne, Laura Rehneke,Silke Lehmann, Jemma Roberts,Melina Altmann,Stefan Altmann, Yingqi Zhang, Eva Köpff,Ana Dominguez-Ferreras, Emeka Okechukwu,Chrysi Sergaki,Charlotte Rich-Griffin,
Nature communicationsno. 1 (2023): 4065-16
Nature Communicationsno. 1 (2023): 1-11
bioRxiv (2021)
Morgan Lee, Anna Dominguez-Ferreras,Ewon Kaliyadasa,Wei-Jie Huang,Edna Antony, Tracey Stevenson,Silke Lehmann,Patrick Schafer,Marc R. Knight,Vardis Ntoukakis,Heather Knight
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