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Bio
The central theme of our research program is the antigenicity of proteins that are targets of paraneoplastic autoimmunity. Synaptic plasma membrane cation channels and neurotransmitter receptors are of particular interest because they readily interact with circulating antibodies. Molecules that are used by tumors for autocrine growth, and possibly metastasis, are in many cases identical to the signaling molecules used by nerve and muscle cells in communicating with each other. The specific antigens we are studying are voltage-gated calcium and potassium channels, nicotinic acetylcholine receptors, and related molecules expressed in carcinomas of lung and ovary, and epithelial thymomas. Tumor proteins of this type initiate the helper T lymphocyte-dependent production of autoantibodies that impair synaptic transmission in the central and peripheral nervous systems.
Research Interests
Papers共 440 篇Author StatisticsCo-AuthorSimilar Experts
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Erin Peterson, Tori E Rudolph,Alison Starr-Moss,Kendall Anderson,Vanda A Lennon,G Diane Shelton,Leigh Anne Clark
Animal geneticsno. 4 (2024): 702-704
Georgios Mangioris,Thorvardur R Halfdanarson,Vanda A Lennon, Bryce K Chang,Divyanshu Dubey,P James B Dyck,Eoin P Flanagan,Andrew McKeon,John R Mills,Sean J Pittock,Anastasia Zekeridou
European journal of neurologyno. 6 (2024): e16273-e16273
ANNALS OF NEUROLOGY (2023): S58-S59
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Clinical Chemistryno. Supplement_1 (2023)
Masoud Majed,Cristina Valencia Sanchez,Jeffrey L Bennett,James Fryer, Martin D Mulligan, Vyankya Redenbaugh,Andrew McKeon,John R Mills,Dean M Wingerchuk,Vanda A Lennon,Brian Weinshenker,John J Chen,
Annals of neurology (2023)
Masoud Majed,Cristina Valencia‐Sánchez,Jeffrey L. Bennett,James P. Fryer, Magdalena Mulligan, Vyankya Redenbaugh,Andrew McKeon,John R. Mills,Dean M. Wingerchuk,Vanda A. Lennon,Brian G. Weinshenker,John J. Chen,
Annals of Neurologyno. 4 (2023): 727-735
Neurologyno. 23 Supplement 2 (2022)
Yong Guo,Vanda A Lennon,Joseph E Parisi, Bogdan Popescu, Christina Vasquez,Sean J Pittock,Charles L Howe,Claudia F Lucchinetti
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