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个人简介
Our research uses mass spectrometry to discover and characterise new lipids (fats) made by circulating vascular cells that regulate immune defence and blood clotting.
Recently we showed that human blood platelets generate a large number of oxidized phospholipids several of which help clotting factors in plasma work more effectively. We also uncovered a new role for phospholipases in providing energy to the cell and how lipids in different people respond individually to aspirin.
Our current research is focused on understanding the role of new lipids in vascular inflammation including cardiovascular disease, dementia and wound healing. Some lipids we discovered are being developed as the basis of new treatments for bleeding excess. Other lipids we showed are anti-inflammatory are being developed as treatments for vascular inflammation, licensed to Complexa Inc, and with a $62M Series C funding investment in 2016
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论文共 172 篇作者统计合作学者相似作者
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Karol Parchem,Sophia Letsiou,Toni Petan,Olga Oskolkova, Isabel Medina,Ondrej Kuda,Valerie B. O'Donnell,Anna Nicolaou,Maria Fedorova,Valery Bochkov,Cécile Gladine
Progress in Lipid Researchpp.101276-101276, (2024)
Matthew J. Conroy,Robert M. Andrews,Simon Andrews, Lauren Cockayne,Edward A. Dennis,Eoin Fahy,Caroline Gaud,William J. Griffiths, Geoff Jukes, Maksim Kolchin, Karla Mendivelso,Andrea F. Lopez-Clavijo,
NUCLEIC ACIDS RESEARCHno. D1 (2024): D1677-D1682
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2024)
medRxiv (Cold Spring Harbor Laboratory) (2023)
Richard Skone,Daniel White,Bethan Phillips,Jennifer Evans,Robert Andrews,Benjamin Saunders,Kerry Hood,Mallinath Chakraborty,Sarah Edkins,Barbara Paquete,Sian Foulkes, Anna Barrow,
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Mass Spectrometry for Lipidomicspp.317-350, (2023)
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Arteriosclerosis, thrombosis, and vascular biologyno. 9 (2023): 1700-1712
Agnieszka Czyżowska,Jacob Brown,Hongyang Xu, Kavitha Sataranatarajan,Michael Kinter,Victoria J. Tyrell,Valerie B. O'Donnell,Holly Van Remmen
Redox Biology (2023): 102761
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Function (Oxford, England)no. 1 (2023)
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