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Research InterestsChatterjee
Our principal research interests are in genetic and molecular endocrinology, with particular emphasis on disorders nuclear hormone synthesis and action. We study several human disorders: Resistance to Thyroid Hormone (RTH), defined broadly as abnormal circulating thyroid hormones with tissue refractoriness to hormone action; and PPARgamma gene defects associated with lipodystrophic insulin resistance. Candidate gene and whole exome approaches are used to identify novel genetic aetiologies mediating defective hormone action. Human phenotypic studies elucidate mechanisms whereby thyroid hormones alter physiological processes acting via receptor subtypes in tissues. In a multisystem selenoprotein deficiency disorder including thyroid deiodinase enzymes, we are investigating features (cardiovascular, metabolic, photosensitivity) attributable to elevated ROS and the roles of selenoproteins of unknown function. Finally, we translate our research into technologies (biochemical, genetic) that comprise our national diagnostic laboratory service, develop biomarkers of hormone action and trial therapies (e.g. selective thyromimetics) that are applicable to commoner thyroid dysfunction or metabolic disorders.
Our principal research interests are in genetic and molecular endocrinology, with particular emphasis on disorders nuclear hormone synthesis and action. We study several human disorders: Resistance to Thyroid Hormone (RTH), defined broadly as abnormal circulating thyroid hormones with tissue refractoriness to hormone action; and PPARgamma gene defects associated with lipodystrophic insulin resistance. Candidate gene and whole exome approaches are used to identify novel genetic aetiologies mediating defective hormone action. Human phenotypic studies elucidate mechanisms whereby thyroid hormones alter physiological processes acting via receptor subtypes in tissues. In a multisystem selenoprotein deficiency disorder including thyroid deiodinase enzymes, we are investigating features (cardiovascular, metabolic, photosensitivity) attributable to elevated ROS and the roles of selenoproteins of unknown function. Finally, we translate our research into technologies (biochemical, genetic) that comprise our national diagnostic laboratory service, develop biomarkers of hormone action and trial therapies (e.g. selective thyromimetics) that are applicable to commoner thyroid dysfunction or metabolic disorders.
研究兴趣
论文共 308 篇作者统计合作学者相似作者
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Luca Persani,Patrice Rodien,Carla Moran, W Edward Visser,Stefan Groeneweg, Robin P Peeters,Samuel Refetoff,Mark Gurnell,Paolo Beck-Peccoz,Krishna Chatterjee
European thyroid journal (2024)
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISMno. 4 (2024): 1094-1108
Mueed Azhar,Laura P E Watson,Emanuella De Lucia Rolfe, Michele Ferraro, Katherine Carr,Jieniean Worsley,Chris Boesch,Leanne Hodson,Krishna K Chatterjee,Graham J Kemp,David B Savage,Alison Sleigh
Carla Moran,Faraneh Vargha‐Khadem,Chris Clark, Kiran K. Seunarine, F. Muntoni, Richard A. I. Bethlehem,Keith Lindley,Laura Watson,Greta Lyons, Mehul Dattani,Krishna Chatterjee
Endocrine Abstracts (2023)
Clinical endocrinologyno. 2 (2023): 206-216
Nature communicationsno. 1 (2023): 3312-11
NATURE COMMUNICATIONSno. 1 (2023)
Laura Watson,Tim J Cole,Greta Lyons, Christopher Georgiou,Jieniean Worsley, Katherine Carr,Peter Murgatroyd,Carla Moran,Krishna Chatterjee,Michelle Venables
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