基本信息
views: 3
Career Trajectory
Bio
Research Abstract
My current research interests are focused on 3 key aspects of skeletal muscle: i) the mechanistic role of contractile and regulatory proteins in muscle mechanics; ii) the mechanistic basis of muscle plasticity; and iii) the application of the first two pursuits to clinically relevant pathologies.
Regarding the first area, previous studies conducted in my laboratory have focused upon the relationship between myosin isoforms and maximal shortening velocity. Current studies are directed at a more complete understanding of the role of myosin using whole muscle, single motor unit, and single fiber studies. Using the novel work loop technique, I have been able to develop a model that describes the role of activation and relaxation processes in limiting the mechanical work produced by skeletal muscle during repetitive contractions. These studies have shown that relaxation plays a major role in limiting the amount of mechanical work that can be produced by skeletal muscle, and that relaxation is length and strain dependent. Future studies with single fibers will specifically focus upon the role of myosin, troponin-C , and the sarcoplasmic reticulum in the relaxation process by using caged chelators of calcium that are activated by laser flash photolysis.
Research Interests
Papers共 179 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Rod Carlo Columbres, Hua Yu,Saya Horiuchi, Tang Bao-pen, Yue Chin, Mathew Gargus,Abhilasha Surampalli,Vincent J. Caiozzo,Hiroshi Yoshioka,Virginia Kimonis
Research Square (Research Square) (2023)
Handbook of Bioastronauticspp.165-180, (2021)
Encyclopedia of Bioastronauticspp.1-14, (2019)
Jake Plewa,Abhilasha Surampalli,Marie Wencel, Merit Milad,Sandra Donkervoort,Vincent J Caiozzo,Namita Goyal,Tahseen Mozaffar,Virginia Kimonis
Load More
Author Statistics
#Papers: 180
#Citation: 5950
H-Index: 46
G-Index: 75
Sociability: 6
Diversity: 3
Activity: 0
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn