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Bio
Dr. Specks is the principal investigator (PI) of laboratory-based research studies designed to characterize the role of the neutrophil serine proteases, proteinase 3 (PR3) and elastase in the pathogenesis of Wegener's granulomatosis, vasculitis and lung fibrosis. Specific aims of these studies are to identify epitopes on the PR3 molecule which are preferentially recognized by PR3-ANCA (autoantibodies from patients with Wegener's granulomatosis), to characterize the effect of such epitope-specific PR3-ANCA on biological functions of PR3, and to determine whether the functional effects of PR3-ANCA have a bearing on specific clinical disease manifestations. Furthermore, the laboratory investigates structure-function relationships of PR3 and elastase and their significance in the pathogenesis of lung fibrosis. These studies have been supported by grants from the American Heart Association, the NIH and the Robert N. Brewer Foundation.
Research Interests
Papers共 577 篇Author StatisticsCo-AuthorSimilar Experts
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The Lancet Rheumatologyno. 5 (2024): e314-e327
Johannes Dieterich,Bernhard Hellmich,Juliane Mahrhold,You-Shan Feng, Abdallah El Rai, Felix Nessyt,Ulrich Specks,Juergen Hetzel,Christian Loeffler
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASESno. 2 (2024): e2024025-e2024025
M.E. Wechsler,D.J. Jackson,U. Specks, C. Pagnoux,N.L. Lugogo,P. Akuthota, P. Baudy, L. Börjesson Sjö,C. McCrae,S. Necander,A. Shavit, C. Walton,
C34. BIOLOGIC THERAPY IN THE FIGHT AGAINST ASTHMA AND ALLERGIC INFLAMMATION (2024)
Kidney International Reportsno. 4 (2024): S136
Kidney international reportsno. 5 (2024): 1284-1297
Kidney International Reportsno. 4 (2024): S135-S136
A26. IMPROVING OUTCOMES IN SARCOIDOSIS, RARE LUNG DISEASE AND LUNG TRANSPLANT (2024)
Marta Casal Moura,Marc Patricio Liebana,Dalia Zubidat, Maria José Vargas,Miriam Machado, Diana Valencia Morales, Sana Abouzahir,Ladan Zand,Ulrich Specks,Sanjeev Sethi,Fernando Fervenza,Maria Jose Soler
Kidney International Reportsno. 4 (2024): S135
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Author Statistics
#Papers: 584
#Citation: 25308
H-Index: 76
G-Index: 149
Sociability: 8
Diversity: 3
Activity: 108
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