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个人简介
Dr. Siebenlist has made many significant contributions to the present understanding of the regulation and function of NF-kappa B transcription factors, which serve as master regulators of numerous immune responses.
This laboratory focuses on the elucidation of molecular mechanisms that operate during immune activation in health and disease. In particular, we try to understand the cellular responses to various pathogens and viruses. Investigations are centered on two issues: 1) identification of signal transduction pathways initiated during immune responses that lead to activation of transcription factors, and 2) functional characterization of the genetic program that is induced by the activated transcription factors.
A true understanding of the roles of factors involved in signal transduction or transcription in the context of an immune response requires the study of immune-challenged animals. Therefore, our research increasingly includes analyses of mice that either overexpress or are deficient for a specific transcription factor or signal-transduction protein.
研究兴趣
论文共 162 篇作者统计合作学者相似作者
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Kamila Guimarães-Pinto,Kamila Guimarães-Pinto, Monique Leandro, Antonia Corrêa, Ester P. Maia, Leticia Rodrigues, André Luiz Amorim da Costa,Jesuino Rafael Machado Ferreira, Estefannia Claudio-Etienne,Ulrich Siebenlist,Jianping He,Thaís da Silva Rigoni,
Frontiers in Immunology (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2022)
The Journal of Immunologyno. 1_Supplement (2021): 110.25-110.25
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Immunology and Cell Biologyno. 6 (2021): 586-595
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