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The goal of my research group is to understand the oncogenic mechanisms that cause malignant transformation of mature B cells and plasma cells.
Cancers of the B-cell lineage, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy. Thus, there is a clinical need for more effective therapies against these malignancies, which requires a better understanding of the biology of these cancers.
My laboratory focusses on the elucidation of the molecular mechanisms that govern the differentiation of B cells. We aim to understand how the disruption of these mechanisms by genetic mutations leads to the development of B-cell and plasma cell malignancies.
Cancers of the B-cell lineage, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy. Thus, there is a clinical need for more effective therapies against these malignancies, which requires a better understanding of the biology of these cancers.
My laboratory focusses on the elucidation of the molecular mechanisms that govern the differentiation of B cells. We aim to understand how the disruption of these mechanisms by genetic mutations leads to the development of B-cell and plasma cell malignancies.
研究兴趣
论文共 131 篇作者统计合作学者相似作者
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Allison Voisin,Maud Plaschka, Marlene Perrin-Niquet,Julie Twardowski, Insaf Boutemine,Baptiste Eluard,Guilhem Lalle,Pierre Stephan, Khaled Bouherrou,Laurie Tonon,Roxane Pommier,Anthony Ferrari,
Allison Voisin,Maud Plaschka, Marlène Perrin-Niquet,Julie Twardowski, Insaf Boutemine,Baptiste Eluard,Guilhem Lalle,Pierre Stéphan, Khaled Bouherrou,Laurie Tonon,Roxane Pommier,Anthony Ferrari,
Frontiers in immunology (2024): 1379777-1379777
Guilhem Lalle,Raphaëlle Lautraite, Khaled Bouherrou,Maud Plaschka, Aurora Pignata,Allison Voisin,Julie Twardowski, Marlène Perrin-Niquet,Pierre Stéphan, Sarah Durget,Laurie Tonon,Maude Ardin,
The Journal of experimental medicineno. 6 (2024)
JOURNAL OF IMMUNOLOGYno. 1 (2023)
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Nature Immunologyno. 8 (2023): 1217-1219
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medRxiv (Cold Spring Harbor Laboratory) (2022)
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