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Aims: We will synthesize molecular probes to investigate the binding pocket of one of the most important enzymes in the glycosaminoglycan biosynthesis, i.e. 4GalT7. The data generated from these probes will be used for design of inhibitors that will be tested in tumor cells.
Feasibility: We have developed assays for important enzymes and built a library of carbohydrate structures. We have a very strong background in synthetic carbohydrate chemistry and in biological investigations.
Aims: We will synthesize molecular probes to investigate the binding pocket of one of the most important enzymes in the glycosaminoglycan biosynthesis, i.e. 4GalT7. The data generated from these probes will be used for design of inhibitors that will be tested in tumor cells.
Feasibility: We have developed assays for important enzymes and built a library of carbohydrate structures. We have a very strong background in synthetic carbohydrate chemistry and in biological investigations.
研究兴趣
论文共 102 篇作者统计合作学者相似作者
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Tiago Bozzola,Mariafrancesca Scalise,Christer U Larsson,Michael C Newton-Vesty, Caterina Rovegno,Ankita Mitra,Jonathan Cramer,Weixiao Yuan Wahlgren, Partha Radhakrishnan Santhakumari,Richard E Johnsson,Oliver Schwardt,Beat Ernst,
Daniel Willén, Roberto Mastio,Zackarias Söderlund,Sophie Manner,Gunilla Westergren-Thorsson,Emil Tykesson,Ulf Ellervik
Bioconjugate chemistryno. 12 (2021): 2507-2515
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