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个人简介
UA’s lab has a long-standing interest in a structure-based understanding of molecular machines, and more generally, supramolecular assemblies by a hybrid methods experimental approach that includes light, electron and scanning probe microscopies, X-ray crystallography, molecular cell biology and protein design. Being problem-driven, he focuses on (1) cytoskeletal filament structure, assembly and turnover; (2) the nuclear pore complex and its involvement in nucleocytoplasmic transport; and (3) fibrillogenesis of amyloid forming peptides and how this relates to disease progression. Also, his group is working on novel optical and mechanical nano-sensors/-actuators for diagnostics, prevention and therapy by minimally invasive local interventions.
In 1981 he co-founded Protek, Inc. to develop, manufacture, and sell hip and knee prostheses in the USA. From 1986 to 1991 he also served on the Technical Board of Protek AG. Since 1996 he has been chairing the Board of Directors of Gehring Cut that develops and manufactures surgical instruments and other precision mechanical components. In 2003 he co-founded Therapeomic, Inc. that focuses on novel protein drug formulations and growth factor enhanced tissue repair. In 2005 he joined the Board of Directors of Alpha-O Peptides, a biotech start-up company that develops novel repetitive antigen display, diagnostic imaging and drug targeting/delivery platforms on the basis of de novo design of polyhedral peptide nanoparticles.
研究兴趣
论文共 562 篇作者统计合作学者相似作者
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Nature Communicationsno. 1 (2020): 1-14
BioRxivno. 1 (2019): 846550-61
Norbert Mücke, Lara Kämmerer,Stefan Winheim,Robert Kirmse,Jan Krieger, Maria Mildenberger,Jochen Baßler,Ed Hurt,Wolfgang H Goldmann,Ueli Aebi,Katalin Toth,Jörg Langowski,
Journal of Nanobiotechnologyno. 1 (2017): 1-2
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGYno. 11 (2016)
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