基本信息
浏览量:0
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Just concluded my PhD at Tumour Institute of Tuscany (ITT) and the University of Florence, Italy.I work in the lab of Dr.Conticello where in we study Molecular Mechanisms of Oncogenesis; our lab focuses on the role of the AID/APOBEC family in the onset and progression of human cancer.
My PhD thesis is titled "Deaminases and beyond: Pathology, Physiology and Biotechnology."
AID/APOBECs have been associated to the onset of cancer through their ability to mutate DNA,finding show another possible cancer-inducing effect of these deaminases: I studied their ability to induce chromosomal instability.
Moreover, recent advances in targeting genomic sequences has revolutionized the genome editing field. Using customized nucleases serves as an ideal platform for targeted deletions, insertion in a broad range of organisms and cell types, but it is less ideal for obtaining changes at specific nucleotides. The fusion of AIDAPOBEC’s to genome editing tool such as Cas9 and TALE has allowed the development of a base editor that aims at avoiding formation of double strand breaks and it offers a new perspective for gene editing. The limit of such base editor is that its targeting is restricted to C•G base pairs. I thus aimed at developing a A•T base editor to induce a single dA to dG mutation. Thus suggesting its potential usage in biotechnological applications such as gene therapy, antiviral treatment and cancer therapy
研究兴趣
论文共 2 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
FEBS JOURNALno. SUPnan (2017): 116-116
引用0浏览0引用
0
0
作者统计
#Papers: 2
#Citation: 0
H-Index: 0
G-Index: 0
Sociability: 1
Diversity: 1
Activity: 0
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn