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Research Abstract
My research seeks answers to the question how circulating blood cells find their way in the body. Directed migration of blood-borne cells to distinct target tissues can be observed in embryos as soon as the circulatory system is established and plays a critical role throughout life in numerous physiologic and pathologic conditions. Despite considerable progress in this field, it is still beyond the reach of even the most sophisticated in vitro methodology to simulate the complex interplay of physical, cellular, biochemical, and other factors that determine blood cell behavior in microvessels. Therefore, we employ intravital microscopy to study the molecular mechanisms of interactions between blood cells and the vascular wall by direct observation in anesthetized mice. Using this approach, we have demonstrated that blood cell homing to most target tissues requires an initial tethering step that leads to rolling in postcapillary venules and is followed by an activation step which, in turn, triggers stationary adhesion and emigration. Each of these three steps (i.e. 1. rolling; 2. chemotactic stimulation; and 3. firm arrest) involves distinct molecular pathways whose unique combination is the reason why certain blood cells migrate to a particular organ, whereas others don't.
My research seeks answers to the question how circulating blood cells find their way in the body. Directed migration of blood-borne cells to distinct target tissues can be observed in embryos as soon as the circulatory system is established and plays a critical role throughout life in numerous physiologic and pathologic conditions. Despite considerable progress in this field, it is still beyond the reach of even the most sophisticated in vitro methodology to simulate the complex interplay of physical, cellular, biochemical, and other factors that determine blood cell behavior in microvessels. Therefore, we employ intravital microscopy to study the molecular mechanisms of interactions between blood cells and the vascular wall by direct observation in anesthetized mice. Using this approach, we have demonstrated that blood cell homing to most target tissues requires an initial tethering step that leads to rolling in postcapillary venules and is followed by an activation step which, in turn, triggers stationary adhesion and emigration. Each of these three steps (i.e. 1. rolling; 2. chemotactic stimulation; and 3. firm arrest) involves distinct molecular pathways whose unique combination is the reason why certain blood cells migrate to a particular organ, whereas others don't.
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Papers共 441 篇Author StatisticsCo-AuthorSimilar Experts
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Samuel W Kazer, Colette Matysiak Match, Erica M Langan,Marie-Angèle Messou,Thomas J LaSalle, Elise O'Leary,Jessica Marbourg,Katherine Naughton,Ulrich H von Andrian,Jose Ordovas-Montanes
bioRxiv : the preprint server for biology (2024)
ISCIENCEno. 1 (2024): 108600-108600
Scientific reportsno. 1 (2024): 14471-14471
Rodrigo J. Gonzalez, Pavel Hanč,David Alvarez,Samuel W. Kazer,Marie-Angele Messou,Irina B. Mazo, Colette Matysiak Match,Rohit Garg,Jennifer D. Helble,Paris Pallis,Rachel Ende,Alan Basset,
biorxiv(2024)
Behnaz Eshaghi,Alex Schudel,Ilin Sadeghi,Ziqi Chen, Amy H. Lee,Maria Kanelli, Flora Tierney,Jooli Han,Bailey Ingalls,David M. Francis, Gary Li,Ulrich von Andrian,
Nature Reviews Materialsno. 1 (2024): 29-45
Samuel W. Kazer, Colette Matysiak Match, Erica M. Langan,Marie-Angèle Messou,Thomas J. LaSalle, Elise O’Leary,Jessica Marbourg,Katherine Naughton,Ulrich H. von Andrian,Jose Ordovas-Montanes
Immunity (2024)
Tianxi Wang,Satoshi Kaneko, Emil Kriukov,David Alvarez,Enton Lam,Yidi Wang,Sara La Manna,Daniela Marasco,Angeles Fernandez-Gonzalez,S. Alex Mitsialis,Stella Kourembanas, Andreas Stahl,
Molecular Therapyno. 5 (2024): 1425-1444
Cell researchpp.1-2, (2024)
Nature communicationsno. 1 (2024): 5449-5449
FRONTIERS IN IMMUNOLOGY (2024): 1277365-1277365
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