Prof Cillo leads, since 2004 a high volume Liver Transplant and Hepatobiliary Surgery Center in Italy. He performed as first surgeon or as tutor over 900 liver transplantations in the adult settings, including split, auxiliary and LDLT and more than 100 pediatric liver transplants (30% <10 kg). He regularly performs interventions of hepatobiliary and pancreatic surgery including major procedures with a particular attitude to the laparoscopic approach (liver resections and ablations - more than 1500 interventions of middle/major hepatobiliary surgery as first surgeon in the last 10 years). 
First to perform auxiliary liver transplants in Italy (2007) and to succeed nationally in the autotransplantation of the liver (ex situ/ex situ liver resections -10 cases performed with no perioperative mortality) . AGENAS (National Agency for Health Regional Services) reported that in 2015 (last report) the Padova University Hepatobiliary and Liver Transplant Unit classified first in Italy for number of hepatobiliary oncologic surgical interventions.
Since 2017 Prof Umberto Cillo is the President of the Italian Society of Organ and Tissue Transplantation (S.I.T.O.) and he’s currently member of the Council of European Society for Organ Transplantation (ESOT). Since 2011 to 2015 he coordinated the liver allocation remodeling in Italy through a process including four methodologically stringent consensus conferences and a public appraisal. The result of the process is the present liver allocation model based on a new scoring system (ISO score) and a blended principle approach.