Trevor moved to Brooklyn, New York to work with Professors Tatyana Pestova and Christopher Hellen to investigate the intricacies of viral protein expression. Here, Trevor demonstrated the essential role of various host proteins in regulating poliovirus protein synthesis and identified and characterised a new class of picornaviral internal ribosomal entry site found in Aichi virus. He has also contributed to our understanding of basic cellular translation revealing important details on the mechanism of translation initiation factors.

While in Brooklyn Trevor also became interested in host mechanisms of restriction by targeting virus translation. He characterised the translation regulatory role of the IFIT family of interferon induced proteins. In 2014 he was awarded a Marie Curie Fellowship to move to the Division of Virology at the University of Cambridge to establish his own lab and from 2016-2025 is supported by a Sir Henry Dale Fellowship sponsored by the Wellcome Trust and Royal Society to study IFIT1 activity and flavivirus replication.