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个人简介
Dr Woodruff is a Professor of Pharmacology who leads a research team aiming to find new therapeutic treatments for neurodegenerative disorders. Current therapies for these diseases are vastly inadequate, and so new research is needed to identify novel targets to slow or halt their progression. Prof Woodruff's specific research revolves around the innate immune system in the brain, and the role of neuroinflammation in propagating disease. A key focus of his current work is testing new drugs developed at the University of Queensland in models of motor neuron disease (amyotrophic lateral sclerosis), Huntington's disease, and Parkinson's disease, as well as maintaining an active interest in acute inflammatory disorders including sepsis and ischemia-reperfusion injuries. Using a series of potent and orally active complement C5a and NLRP3 inflammasome inhibitors developed at UQ, Prof Woodruff's team has demonstrated the therapeutic potential of targeting innate immune-mediated neuroinflammation to reduce neuronal cell death in animal models of these neurodegenerative diseases. His team has recently shown that in addition to their roles in neurodegeneration, innate immune factors also play essential roles in stem and neuronal cell development during embryogenesis, revealing the widespread physiological and pathological roles of this evolutionarily ancient immune system.
研究兴趣
论文共 332 篇作者统计合作学者相似作者
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Proceedings of the National Academy of Sciences of the United States of Americano. 5 (2024): e2314627121-e2314627121
Elsevier eBookspp.41-60.e10, (2024)
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Caixia Lin,Margreet Ridder,Jinhao Zhong,Eduardo A. Albornoz,Petra Sedlak,Li Xu,Trent M. Woodruff, Fangyi Chen,Pankaj Sah
biorxiv(2024)
ASPET 2024 Annual Meeting Abstract - Cancer Pharmacology (2024)
Robert P Krattli, An H Do, Sanad M El-Khatib,Leila Alikhani,Mineh Markarian, Arya R Vagadia,Manal T Usmani, Shreya Madan,Janet E Baulch,Richard J Clark,Trent M Woodruff,Andrea J Tenner,
bioRxiv : the preprint server for biology (2024)
Jennifer Stables, Reiss Pal,Barry M. Bradford,Dylan Carter-Cusack, Isis Taylor, Clare Pridans, Nemat Khan,Trent Woodruff, Katharine M. Irvine,Kim M. Summers, Neil A. Mabbott,David A. Hume
biorxiv(2024)
Trends in Immunologyno. 6 (2024): 397-399
Kiley Christopher,Alex Keyes, Kavita Solanki, Yaroslav Andrianov,L. Shutov, C Warwick,Trent Woodruff,P. Belan,N. Voitenko,Yuriy Usachev
The Journal of Painno. 4 (2024): 5
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCEno. 3 (2024): 100306-100306
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#Papers: 328
#Citation: 12788
H-Index: 60
G-Index: 104
Sociability: 7
Diversity: 4
Activity: 119
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