基本信息
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个人简介
Key Contributions
Solved the first structure of a chemokine receptor, CXCR4, with a chemokine
Defined for the first time, the activation pathway from chemokine to G protein through the transmembrane helices of chemokine receptor, CXCR4
Determined the structure of CCR2 simultaneously bound to an orthosteric and an allosteric antagonist and defined novel mechanisms for inhibiting the receptor.
Determine the structure of CCR5 in complex with chemokine, and showed how HIV GP120 likely mimics chemokine interactions with receptors as a mechanism for HIV to enter cells.
Discovered several novel mechanisms of receptor antagonism based on modified chemokines. Developed novel methods to select for high affinity chemokine antagonists.
Discovered novel mechanisms by which chemokines contribute to cancer, and the potential of small molecule inhibitors for CLL.
研究兴趣
论文共 192 篇作者统计合作学者相似作者
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Grant Wadman,Irina Kufareva, John Dawson,Penglie Zhang,Andrew Tebben,Percy Carter, Siyi Gu, Thomas Shroka, Leire Borrega-Roman,Catherina Salanga,Tracy Handel
ASPET 2024 Annual Meeting Abstract - Cellular and Molecular Pharmacology (2024)
bioRxiv : the preprint server for biology (2023)
Molecular Pharmacologyno. 4 (2023): 174-186
PROTEIN SCIENCE (2023)
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STAR protocolsno. 3 (2023): 102460-102460
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Siyi Gu, Svetlana Maurya, Alexis Lona, Leire Borrega-Roman,Catherina Salanga, David J. Gonzalez,Irina Kufareva,Tracy M. Handel
bioRxiv the preprint server for biology (2023)
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