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Research Interests and Techniques
My lab is interested in how chromatin remodelling and gene regulatory networks drive the maturation and differentiation of neurons in the developing nervous system. When a neuron is born, it still has a long way to go before it is a full functional unit in the nervous system. Much has been learnt about the cellular changes that a neuron undergoes as it matures, however, much less is known about the chromatin remodelling process that are occurring during neuronal maturation. Our recent paper in eLife (Hassan et al., 2020) implicates a component of the condensin complex in this process.
We use the cell-type specific profiling technique TaDa (Southall et al. 2013) to map the transcriptional state, and the genomic binding of regulatory factors, and have also developed CATaDa for profiling chromatin accessibility in vivo in a cell-specific manner (Aughey et al., 2018)
My lab is interested in how chromatin remodelling and gene regulatory networks drive the maturation and differentiation of neurons in the developing nervous system. When a neuron is born, it still has a long way to go before it is a full functional unit in the nervous system. Much has been learnt about the cellular changes that a neuron undergoes as it matures, however, much less is known about the chromatin remodelling process that are occurring during neuronal maturation. Our recent paper in eLife (Hassan et al., 2020) implicates a component of the condensin complex in this process.
We use the cell-type specific profiling technique TaDa (Southall et al. 2013) to map the transcriptional state, and the genomic binding of regulatory factors, and have also developed CATaDa for profiling chromatin accessibility in vivo in a cell-specific manner (Aughey et al., 2018)
研究兴趣
论文共 72 篇作者统计合作学者相似作者
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Alexandra Mancheno-Ferris,Clement Immarigeon,Alexia Rivero,David Depierre, Naomi Schickele,Olivier Fosseprez, Nicolas Chanard,Gabriel Aughey, Priscilla Lhoumaud,Julien Anglade,Tony Southall,Serge Plaza,
ISCIENCEno. 1 (2024): 108624-108624
Alexandra Mancheno-Ferris,Clément Immarigeon,Alexia Rivero,David Depierre, Nicolas Chanard,Olivier Fosseprez,Gabriel Aughey, Priscilla Lhoumaud,Julien Anglade,Tony Southall,Serge Plaza,Olivier Cuvier,
crossref(2023)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
Guillermo Martínez Corrales,Mengjia Li, Tatiana Svermova, Alex Goncalves,Diana Voicu,Adam J. Dobson,Tony D. Southall,Nazif Alic
Rafael Sênos Demarco, Brian J Stack, Alexander M Tang,Justin Voog,Sharsti L Sandall,Tony D Southall,Andrea H Brand,D Leanne Jones
Cell reportsno. 3 (2022): 110679-110679
Colin D McClure,Amira Hassan,Gabriel N Aughey, Khushbakht Butt,Alicia Estacio-Gómez, Aneisha Duggal,Chee Ying Sia,Annika F Barber,Tony D Southall
crossref(2022)
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