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To maintain genetic integrity, a whole set of chromosomes must be inherited by daughter cells when cell division occurs. This process relies on chromosome segregation in mitosis. Errors in chromosome segregation would cause cell death and various human diseases such as congenital disorders and cancers. The research in his group focuses on two major events in early mitosis, by which chromosomes become prepared for segregation– first, chromosome re-organization involving resolution and compaction of sister chromatids; second, interactions between chromosomes and the mitotic spindle, which provide forces for chromosome segregation later in mitosis. His research aims to reveal fundamental mechanisms ensuring chromosome segregation and thus to understand the mechanisms of relevant human diseases.
Research Interests
Papers共 194 篇Author StatisticsCo-AuthorSimilar Experts
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Journal of applied crystallographyno. Pt 5 (2023): 1361-1370
Proceedings of the National Academy of Sciences of the United States of Americano. 9 (2022)
BioEssaysno. 5 (2022)
semanticscholar(2022)
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#Papers: 197
#Citation: 12553
H-Index: 53
G-Index: 111
Sociability: 7
Diversity: 0
Activity: 1
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