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Iron is an essential trace element whose plasma concentrations must be maintained in a narrow range. Prolonged decrease in plasma iron concentration causes cellular iron deficiency and anemia, and prolonged increase causes iron toxicity leading to organ failure and death. Our group discovered the iron-regulatory hormone hepcidin and, together with others, characterized its effects, regulation and mechanism of action. Hepcidin binds to the cellular iron channel/receptor ferroportin and induces its internalization and degradation. We are studying the molecular pathways involved in hepcidin and ferroportin regulation, and developing lead candidates for the treatment of iron disorders, including hereditary hemochromatosis and various anemias. Experimental approaches range from molecular analysis of gene and protein regulation in cell lines and transgenic mice, synthetic production and testing of natural and modified peptides, to histopathologic studies and assays of samples from human patients and experimental animals.
Iron is an essential trace element whose plasma concentrations must be maintained in a narrow range. Prolonged decrease in plasma iron concentration causes cellular iron deficiency and anemia, and prolonged increase causes iron toxicity leading to organ failure and death. Our group discovered the iron-regulatory hormone hepcidin and, together with others, characterized its effects, regulation and mechanism of action. Hepcidin binds to the cellular iron channel/receptor ferroportin and induces its internalization and degradation. We are studying the molecular pathways involved in hepcidin and ferroportin regulation, and developing lead candidates for the treatment of iron disorders, including hereditary hemochromatosis and various anemias. Experimental approaches range from molecular analysis of gene and protein regulation in cell lines and transgenic mice, synthetic production and testing of natural and modified peptides, to histopathologic studies and assays of samples from human patients and experimental animals.
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论文共 755 篇作者统计合作学者相似作者
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Trends in endocrinology and metabolism: TEM (2024)
Akhila Vadivelan, Sarah Zhang,Daniel N. Srole, Elizabeth A. Marcus, George Carvalho Neto,Elizabeta Nemeth,Tomas Ganz,Satiro De Oliveira
Haematologica (2024)
Bloodno. 11 (2024): 1045-1049
bioRxiv : the preprint server for biology (2023)
Jihyun Song,Krishna M Sundar,Monika Horvathova,Radhika Gangaraju, Karel Indrak,Robert D Christensen, Samuel Genzor, Carsten Lundby,Vladimir Divoky,Tomas Ganz,Josef T Prchal
American journal of hematologyno. 8 (2023): 1265-1276
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American journal of hematologyno. 10 (2023): 1532-1539
Bloodno. Supplement 1 (2023): 924-924
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