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个人简介
The Muir lab investigates the physiochemical basis of protein function in complex systems of biomedical interest. We study protein function using an integration of synthetic organic and physical chemistry tools in combination with those of molecular genetics. Driven by a series of biological questions, we have developed general chemical biology approaches that allow the covalent structure of proteins to be manipulated with a similar level of control to those possible with smaller organic molecules. These technologies, which can be applied both in vitro and in vivo, allow the insertion of unnatural amino acids, posttranslational modifications and isotopic probes site-specifically anywhere into proteins. Our innovative methods are now used by numerous laboratories worldwide to address a large number of biomedical questions.
研究兴趣
论文共 362 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Benjamin A Nacev,Yakshi Dabas, Matthew R Paul, Christian Pacheco,Michelle Mitchener, Yekaterina Perez, Yan Fang,Alexey A Soshnev, Douglas Barrows, Thomas Carroll,Nicholas D Socci,Samantha C St Jean,
Nature communicationsno. 1 (2024): 5155-5155
Nature chemical biology (2024)
bioRxiv the preprint server for biology (2023)
CELLno. 10 (2023): 2280-2280
Nature reviews. Geneticsno. 4 (2023): 255-271
Ciaran P. Seath, Antony J. Burton, Xuemeng Sun, Gihoon Lee,Ralph E. Kleiner, David W. C. MacMillan,Tom W. Muir
NATUREno. 7957 (2023): 574-+
bioRxiv : the preprint server for biology (2023)
Biographical Memoirs of Fellows of the Royal Society (2023): 387-409
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